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'''O-2694''' is a drug that is a [[cannabinoid]] derivative. It has [[analgesic]] effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both [[cannabinoid receptor 1|CB<sub>1</sub>]] and [[cannabinoid receptor 2|CB<sub>2</sub>]] [[Receptor (biochemistry)|receptors]], with [[Dissociation constant|''K''<sub>i</sub>]] values of 3.7 nM at CB<sub>1</sub> and 2.8 nM at CB<sub>2</sub>. However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the [[ester]] link to the water-insoluble compound [[O-2372]], thus producing a biphasic effects profile that is less suitable for research purposes than the related compound [[O-2545]].<ref>{{cite journal | vauthors = Martin BR, Wiley JL, Beletskaya I, Sim-Selley LJ, Smith FL, Dewey WL, Cottney J, Adams J, Baker J, Hill D, Saha B, Zerkowski J, Mahadevan A, Razdan RK | display-authors = 6 | title = Pharmacological characterization of novel water-soluble cannabinoids | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 318 | issue = 3 | pages = 1230–9 | date = September 2006 | pmid = 16757541 | doi = 10.1124/jpet.106.104109 }}</ref> |
'''O-2694''' is a drug that is a [[cannabinoid]] derivative. It has [[analgesic]] effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both [[cannabinoid receptor 1|CB<sub>1</sub>]] and [[cannabinoid receptor 2|CB<sub>2</sub>]] [[Receptor (biochemistry)|receptors]], with [[Dissociation constant|''K''<sub>i</sub>]] values of 3.7 nM at CB<sub>1</sub> and 2.8 nM at CB<sub>2</sub>. However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the [[ester]] link to the water-insoluble compound [[O-2372]], thus producing a biphasic effects profile that is less suitable for research purposes than the related compound [[O-2545]].<ref>{{cite journal | vauthors = Martin BR, Wiley JL, Beletskaya I, Sim-Selley LJ, Smith FL, Dewey WL, Cottney J, Adams J, Baker J, Hill D, Saha B, Zerkowski J, Mahadevan A, Razdan RK | display-authors = 6 | title = Pharmacological characterization of novel water-soluble cannabinoids | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 318 | issue = 3 | pages = 1230–9 | date = September 2006 | pmid = 16757541 | doi = 10.1124/jpet.106.104109 | s2cid = 14864925 }}</ref> |
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== See also == |
== See also == |
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Revision as of 02:06, 7 September 2020
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| Chemical and physical data | |
| Formula | C38H60N2O5 |
| Molar mass | 624.907 g·mol−1 |
| 3D model (JSmol) | |
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O-2694 is a drug that is a cannabinoid derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both CB1 and CB2 receptors, with Ki values of 3.7 nM at CB1 and 2.8 nM at CB2. However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the ester link to the water-insoluble compound O-2372, thus producing a biphasic effects profile that is less suitable for research purposes than the related compound O-2545.[1]
See also
References
- ^ Martin BR, Wiley JL, Beletskaya I, Sim-Selley LJ, Smith FL, Dewey WL, et al. (September 2006). "Pharmacological characterization of novel water-soluble cannabinoids". The Journal of Pharmacology and Experimental Therapeutics. 318 (3): 1230–9. doi:10.1124/jpet.106.104109. PMID 16757541. S2CID 14864925.