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'''O-2694''' is a drug that is a [[cannabinoid]] derivative. It has [[analgesic]] effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both [[cannabinoid receptor 1|CB<sub>1</sub>]] and [[cannabinoid receptor 2|CB<sub>2</sub>]] [[Receptor (biochemistry)|receptors]], with [[Dissociation constant| |
'''O-2694''' is a drug that is a [[cannabinoid]] derivative. It has [[analgesic]] effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both [[cannabinoid receptor 1|CB<sub>1</sub>]] and [[cannabinoid receptor 2|CB<sub>2</sub>]] [[Receptor (biochemistry)|receptors]], with [[Dissociation constant|K<sub>i</sub>]] values of 3.7nM at CB<sub>1</sub> and 2.8nM at CB<sub>2</sub>. However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the [[ester]] link to the water-insoluble compound [[O-2372]], thus producing a biphasic effects profile that is less suitable for research purposes than the related compound [[O-2545]].<ref>Martin BR, ''et al.'' Pharmacological characterization of novel water-soluble cannabinoids. ''Journal of Pharmacology and Experimental Therapeutics''. 2006 Sep;318(3):1230-9. PMID 16757541</ref> |
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==See also== |
==See also== |
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==References== |
==References== |
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Revision as of 03:00, 13 October 2012
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| Identifiers | |
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| PubChem CID | |
| Chemical and physical data | |
| Formula | C38H60N2O5 |
| Molar mass | 624.891 g/mol g·mol−1 |
| 3D model (JSmol) | |
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O-2694 is a drug that is a cannabinoid derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both CB1 and CB2 receptors, with Ki values of 3.7nM at CB1 and 2.8nM at CB2. However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the ester link to the water-insoluble compound O-2372, thus producing a biphasic effects profile that is less suitable for research purposes than the related compound O-2545.[1]
See also
References
- ^ Martin BR, et al. Pharmacological characterization of novel water-soluble cannabinoids. Journal of Pharmacology and Experimental Therapeutics. 2006 Sep;318(3):1230-9. PMID 16757541