Cannabis Ruderalis

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'''JWH-210''' is an [[analgesic]] chemical from the [[naphthoylindole]] family, which acts as a potent [[cannabinoid]] agonist at both the [[Cannabinoid receptor 1|CB<sub>1</sub>]] and [[Cannabinoid receptor 2 (macrophage)|CB<sub>2</sub>]] receptors, with K<sub>i</sub> values of 0.46nM at CB<sub>1</sub> and 0.69nM at CB<sub>2</sub>. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher [[Dissociation constant#Protein-ligand binding|binding affinity]] (i.e. lower K<sub>i</sub>) at CB<sub>1</sub> than both its 4-methyl and 4-''n''-propyl [[homolog (chemistry)|homologue]]s [[JWH-122]] (CB<sub>1</sub> K<sub>i</sub> 0.69nM) and [[JWH-182]] (CB<sub>1</sub> K<sub>i</sub> 0.65nM) respectively, and than the 4-methoxy compound [[JWH-081]] (CB<sub>1</sub> K<sub>i</sub> 1.2nM).<ref>{{Cite pmid|15582455}}</ref> It was discovered by and named after Dr. [[John W. Huffman]]. JWH-210 and JWH-122 were banned in Sweden on 1st October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" [[synthetic cannabis]] products.<ref>[http://www.riksdagen.se/webbnav/index.aspx?nid=3911&bet=1999:58 Swedish Code of Statutes Regulation (2010:1086).]</ref><ref>[http://www.lagboken.se/files/SFS/2010/101086.PDF Swedish Code of Statutes Regulation (2010:1086). (pdf)]</ref> The substance JWH-210, JWH-122 and [[JWH-203]] were classified as illegal drugs by the Swedish government as of 1 September, 2011.<ref>LVFS 2011:8</ref>
'''JWH-210''' is an [[analgesic]] chemical from the [[naphthoylindole]] family, which acts as a potent [[cannabinoid]] agonist at both the [[Cannabinoid receptor 1|CB<sub>1</sub>]] and [[Cannabinoid receptor 2 (macrophage)|CB<sub>2</sub>]] receptors, with K<sub>i</sub> values of 0.46nM at CB<sub>1</sub> and 0.69nM at CB<sub>2</sub>. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher [[Dissociation constant#Protein-ligand binding|binding affinity]] (i.e. lower K<sub>i</sub>) at CB<sub>1</sub> than both its 4-methyl and 4-''n''-propyl [[homolog (chemistry)|homologue]]s [[JWH-122]] (CB<sub>1</sub> K<sub>i</sub> 0.69nM) and [[JWH-182]] (CB<sub>1</sub> K<sub>i</sub> 0.65nM) respectively, and than the 4-methoxy compound [[JWH-081]] (CB<sub>1</sub> K<sub>i</sub> 1.2nM).<ref>{{Cite pmid|15582455}}</ref> It was discovered by and named after Dr. [[John W. Huffman]]. JWH-210 and JWH-122 were banned in Sweden on 1st October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" [[synthetic cannabis]] products.<ref>[http://www.riksdagen.se/webbnav/index.aspx?nid=3911&bet=1999:58 Swedish Code of Statutes Regulation (2010:1086).]</ref><ref>[http://www.lagboken.se/files/SFS/2010/101086.PDF Swedish Code of Statutes Regulation (2010:1086). (pdf)]</ref> The substance JWH-210, JWH-122 and [[JWH-203]] were classified as illegal drugs by the Swedish government as of 1 September, 2011.<ref>LVFS 2011:8</ref>


Effects
==Effects==
Out of all the JWH chemicals, JWH-210 is most known to produce effects similar to that of a sativa-type cannabis. <ref>{{cite web|first=CulianJope|title=Re: Jwh-210 Experiences|url=http://www.drugs-forum.com/forum/showthread.php?t=140647|accessdate=7 November 2011}}</ref>
Out of all the JWH chemicals, JWH-210 is most known to produce effects similar to that of a sativa-type cannabis. <ref>{{cite web|first=CulianJope|title=Re: Jwh-210 Experiences|url=http://www.drugs-forum.com/forum/showthread.php?t=140647|accessdate=7 November 2011}}</ref>


Revision as of 23:47, 25 November 2011

JWH-210
Legal status
Legal status
  • Illegal in Sweden,I-N(Poland)[1]
Identifiers
  • 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.233.380 Edit this at Wikidata
Chemical and physical data
FormulaC26H27NO
Molar mass369.498 g/mol g·mol−1
3D model (JSmol)
  • c4cccc2c4c(CC)ccc2C(=O)c(c3)c1ccccc1n3CCCCC
  (verify)

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB1 Ki 0.69nM) and JWH-182 (CB1 Ki 0.65nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2nM).[2] It was discovered by and named after Dr. John W. Huffman. JWH-210 and JWH-122 were banned in Sweden on 1st October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" synthetic cannabis products.[3][4] The substance JWH-210, JWH-122 and JWH-203 were classified as illegal drugs by the Swedish government as of 1 September, 2011.[5]

Effects

Out of all the JWH chemicals, JWH-210 is most known to produce effects similar to that of a sativa-type cannabis. [6]

See also

References

  1. ^ = WDU20111050614 "Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii ( Dz.U. 2011 nr 105 poz. 614 )". Internetowy System Aktów Prawnych. Retrieved 12 June 2011. {{cite web}}: Check |url= value (help)
  2. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15582455, please use {{cite journal}} with |pmid=15582455 instead.
  3. ^ Swedish Code of Statutes Regulation (2010:1086).
  4. ^ Swedish Code of Statutes Regulation (2010:1086). (pdf)
  5. ^ LVFS 2011:8
  6. ^ "Re: Jwh-210 Experiences". Retrieved 7 November 2011. {{cite web}}: |first= missing |last= (help)


source: https://en.wikipedia.org/w/index.php?title=JWH-210&diff=prev&oldid=462481602

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