'''JWH-210''' is an [[analgesic]] chemical from the [[naphthoylindole]] family, which acts as a potent [[cannabinoid]] agonist at both the [[Cannabinoid receptor 1|CB₁]] and [[Cannabinoid receptor 2 (macrophage)|CB₂]] receptors, with K_i values of 0.46nM at CB₁ and 0.69nM at CB₂. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher [[Dissociation constant#Protein-ligand binding|binding affinity]] (i.e. lower K_i) at CB₁ than both its 4-methyl and 4-''n''-propyl [[homolog (chemistry)|homologue]]s [[JWH-122]] (CB₁ K_i 0.69 nM) and [[JWH-182]] (CB₁ K_i 0.65 nM) respectively, and than the 4-methoxy compound [[JWH-081]] (CB₁ K_i 1.2 nM).<ref>{{Cite pmid|15582455}}</ref> It was discovered by and named after Dr. [[John W. Huffman]]. JWH-210 and JWH-122 were banned in Sweden on 1st October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" [[synthetic cannabis]] products.<ref>[http://www.riksdagen.se/webbnav/index.aspx?nid=3911&bet=1999:58 Swedish Code of Statutes Regulation (2010:1086).]</ref><ref>[http://www.lagboken.se/files/SFS/2010/101086.PDF Swedish Code of Statutes Regulation (2010:1086). (pdf)]</ref> A urine test for JWH-122 was developed in 2011, after its widespread use in [[synthetic cannabis]] smoking blends.<ref name="pmid21482054">{{cite journal |author=Ernst L, Schiebel HM, Theuring C, Lindigkeit R, Beuerle T |title=Identification and characterization of JWH-122 used as new ingredient in "Spice-like" herbal incenses |journal=Forensic Science International |volume=208 |issue=1-3 |pages=e31–5 |year=2011 |month=May |pmid=21482054 |doi=10.1016/j.forsciint.2011.03.020 |url=}}</ref>

[[Image:JWH-122andJWH-182.png|280px|thumb|left|JWH-122 and JWH-182]]{{clear-left}}