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'''JWH-210''' is an [[analgesic]] chemical from the aminoalkylindole family, which acts as a potent [[cannabinoid]] agonist at both the CB<sub>1</sub> and CB<sub>2</sub> receptors, with Ki = 0.46nM at CB<sub>1</sub> and 0.69nM at CB<sub>2</sub>. It is one of the most potent 4-substituted naphthoyl derivatives in the aminoalkylindole series, having a higher [[Dissociation constant#Protein-Ligand binding|binding affinity]] than both its 4-methyl and 4-''n''-propyl [[homolog (chemistry)|homologue]]s (JWH-122 and JWH-182 respectively), and than the 4-methoxy compound [[JWH-081]].<ref>{{Cite pmid|15582455}}</ref> |
'''JWH-210''' is an [[analgesic]] chemical from the aminoalkylindole family, which acts as a potent [[cannabinoid]] agonist at both the CB<sub>1</sub> and CB<sub>2</sub> receptors, with Ki = 0.46nM at CB<sub>1</sub> and 0.69nM at CB<sub>2</sub>. It is one of the most potent 4-substituted naphthoyl derivatives in the aminoalkylindole series, having a higher [[Dissociation constant#Protein-Ligand binding|binding affinity]] (i.e. lower Ki) than both its 4-methyl and 4-''n''-propyl [[homolog (chemistry)|homologue]]s (JWH-122 and JWH-182 respectively), and than the 4-methoxy compound [[JWH-081]].<ref>{{Cite pmid|15582455}}</ref> |
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==See also== |
==See also== |
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Revision as of 03:27, 22 March 2010
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| Identifiers | |
|---|---|
| |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.233.380 |
| Chemical and physical data | |
| Formula | C26H27NO |
| Molar mass | 369.498 g/mol g·mol−1 |
| 3D model (JSmol) | |
| |
JWH-210 is an analgesic chemical from the aminoalkylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki = 0.46nM at CB1 and 0.69nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the aminoalkylindole series, having a higher binding affinity (i.e. lower Ki) than both its 4-methyl and 4-n-propyl homologues (JWH-122 and JWH-182 respectively), and than the 4-methoxy compound JWH-081.[1]
See also
References
- ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15582455, please use {{cite journal}} with
|pmid=15582455instead.