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==References==
==References==
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[[Category:NS5A inhibitors]]
[[Category:NS5A inhibitors]]

Revision as of 12:49, 20 April 2024

Coblopasvir
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • Methyl N-[(2S)-1-[(2S)-2-[5-[4-[7-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-1,3-benzodioxol-4-yl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CAS Number
PubChem CID
DrugBank
UNII
Chemical and physical data
FormulaC41H50N8O8
Molar mass782.899 g·mol−1

Coblopasvir is a pharmaceutical drug for the treatment of hepatitis C.[1]

In China, it is approved for use in combination with sofosbuvir for treating naïve or interferon‐experienced adults chronically monoinfected patients with HCV of genotype 1, 2, 3 and 6, with or without compensated cirrhosis.[2]

References

  1. ^ Rao, Huiying; Song, Guangjun; Li, Guangming; Yang, Yongfeng; Wu, Xiaofeng; Guan, Yujuan; Mao, Qing; Jiang, Xiangjun; Wang, Changyuan; Zhang, Ying; Jia, Jidong; Guo, Xiaolin; Li, Chenghao; Ning, Jing; Qin, Hong; Pan, Hai; Wei, Lai (2020). "Safety and efficacy of coblopasvir and sofosbuvir in patients with genotypes 1, 2, 3 and 6 HCV infections without or with compensated cirrhosis". Journal of Viral Hepatitis. 27 (1): 45–51. doi:10.1111/jvh.13208. PMID 31520460.
  2. ^ Gao, Yanhang; Kong, Fei; Li, Guangming; Li, Cheng; Zheng, Sujun; Lin, Jianmei; Wen, Xiaofeng; Hu, Jinghua; Wang, Xiaozhong; Wu, Xiaofeng; Xing, Huichun; Jia, Jidong; Jia, Zhansheng; Guan, Yujuan; Li, Chenghao; Wu, Guicheng; Gao, Zhiliang; Mou, Zhuangbo; Ning, Qin; Mao, Qing; Yang, Yongfeng; Ning, Jing; Li, Li; Pan, Hai; Zhou, Desheng; Ding, Yanhua; Qin, Hong; Niu, Junqi (2020). "Coblopasvir and sofosbuvir for treatment of chronic hepatitis C virus infection in China: A single-arm, open-label, phase 3 trial". Liver International. 40 (11): 2685–2693. doi:10.1111/liv.14633. PMC 7702130. PMID 33047868.

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