Identifiers | |
---|---|
| |
CAS Number |
|
PubChem CID | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C21H30O2 |
Molar mass | 314.469 g·mol−1 |
3D model (JSmol) | |
| |
|
Cannabicitran (CBTC) is a phytocannabinoid first isolated in 1974 as a trace component of Cannabis sativa,[1][2][3][4] and also found in some other plants.[5][6] It is not psychoactive, but was found to reduce intraocular pressure in tests on rabbits,[7] which may reflect agonist activity at the NAGly receptor (formally GPR18) that is known to be a target of many structurally related cannabinoids.[8]
See also
References
- ^ Bercht CAL, et al. Cannabicitran: A new naturally occurring tetracyclic diether from lebanese Cannabis sativa. Phytochemistry 1974; 13(3): 619-621. doi:10.1016/S0031-9422(00)91362-1
- ^ Ross SA, ElSohly MA, Sultana GN, Mehmedic Z, Hossain CF, Chandra S. Flavonoid glycosides and cannabinoids from the pollen of Cannabis sativa L. Phytochem Anal. 2005 Jan-Feb;16(1):45-8. doi:10.1002/pca.809 PMID 15688956
- ^ Radwan MM, Chandra S, Gul S, ElSohly MA. Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis. Molecules. 2021 May 8;26(9):2774. doi:10.3390/molecules26092774 PMID 34066753
- ^ Hanuš LO, Meyer SM, Muñoz E, Taglialatela-Scafati O, Appendino G (November 2016). "Phytocannabinoids: a unified critical inventory". Natural Product Reports. 33 (12): 1357–1392. doi:10.1039/c6np00074f. PMID 27722705.
- ^ Lee YR, Kim JH. Efficient Synthesis of Polycycles by Electrocyclizations of Substituted Trihydroxybenzenes: Synthesis of Rubranine and Deoxybruceol. Synlett 2007; 14: 2232-2236. doi:10.1055/s-2007-985562
- ^ Iwata N, Kitanaka S. New cannabinoid-like chromane and chromene derivatives from Rhododendron anthopogonoides. Chem Pharm Bull (Tokyo). 2011;59(11):1409-12. doi:10.1248/cpb.59.1409 PMID 22041081
- ^ ElSohly MA, Harland EC, Benigni DA, Waller CW. Cannabinoids in glaucoma II: the effect of different cannabinoids on intraocular pressure of the rabbit. Curr Eye Res. 1984 Jun;3(6):841-50. doi: 10.3109/02713688409000797. PMID: 6329602
- ^ Caldwell MD, Hu SS, Viswanathan S, Bradshaw H, Kelly ME, Straiker A (June 2013). "A GPR18-based signalling system regulates IOP in murine eye". British Journal of Pharmacology. 169 (4): 834–43. doi:10.1111/bph.12136. PMC 3687663. PMID 23461720.