Alyx may refer to:

• The Adventures of Alyx, a 1976 collection of feminist science fiction stories by American writer Joanna Russ
• ALyX, a season-two contestant on the American singing competition television series The Voice
• Alyx Vance, a non-player character in Valve's 2004 first-person shooter video game Half-Life 2
• Half-Life: Alyx, a 2020 virtual reality first-person shooter developed and published by Valve