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Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: ChemSpiderID StdInChI StdInChIKey SMILES1. |
Updating {{drugbox}} (no changed fields - added verified revid - updated 'UNII_Ref', 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref') per Chem/Drugbox validation (report [[Wikipedia talk:Wi |
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{{Drugbox| |
{{Drugbox| verifiedrevid = 401783334 |
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|IUPAC_name = (6aR,10aR)-3-(1-hexylcyclopropyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol |
|IUPAC_name = (6aR,10aR)-3-(1-hexylcyclopropyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol |
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| image = AMG-41.svg |
| image = AMG-41.svg |
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| width= 240 |
| width= 240 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 8537151 |
| ChemSpiderID = 8537151 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C25H36O2/c1-5-6-7-8-11-25(12-13-25)18-15-21(26)23-19-14-17(2)9-10-20(19)24(3,4)27-22(23)16-18/h9,15-16,19-20,26H,5-8,10-14H2,1-4H3/t19-,20-/m1/s1 |
| StdInChI = 1S/C25H36O2/c1-5-6-7-8-11-25(12-13-25)18-15-21(26)23-19-14-17(2)9-10-20(19)24(3,4)27-22(23)16-18/h9,15-16,19-20,26H,5-8,10-14H2,1-4H3/t19-,20-/m1/s1 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = UVQIBKXDOZWHFU-WOJBJXKFSA-N |
| StdInChIKey = UVQIBKXDOZWHFU-WOJBJXKFSA-N |
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| smiles1 = Oc2cc(cc1OC([C@@H]3C/C=C(\C[C@H]3c12)C)(C)C)C4(CCCCCC)CC4 |
| smiles1 = Oc2cc(cc1OC([C@@H]3C/C=C(\C[C@H]3c12)C)(C)C)C4(CCCCCC)CC4 |
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Revision as of 14:58, 11 December 2010
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| Identifiers | |
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| PubChem CID | |
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| Chemical and physical data | |
| Formula | C25H36O2 |
| Molar mass | 368.551 g/mol g·mol−1 |
| 3D model (JSmol) | |
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AMG-41 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC substituted with a cyclopropane group on the 3-position side chain. AMG-41 is a potent agonist at both CB1 and CB2, with a Ki of 0.4nM at CB1 vs 0.9nM at CB2.[1][2][3]
References
- ^ Papahatjis DP, Nikas SP, Andreou T, Makriyannis A. Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols. Bioorganic and Medicinal Chemistry Letters. 2002 Dec 16;12(24):3583-6. PMID 12443781
- ^ Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753
- ^ Papahatjis DP, Nahmias VR, Nikas SP, Andreou T, Alapafuja SO, Tsotinis A, Guo J, Fan P, Makriyannis A. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of Medicinal Chemistry. 2007 Aug 23;50(17):4048-60. PMID 17672444