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{{Short description|Chemical compound}}
{{Drugbox
| verifiedrevid =
| IUPAC_name = (6aR,10aR)-3-(1-hexylcyclopropyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
| image = AMG-41.svg
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| tradename =
| legal_status =
| routes_of_administration =
<!--Pharmacokinetic data-->
| metabolism =
| elimination_half-life =
| excretion =
<!--Identifiers-->
| CAS_number = 499237-35-3
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 3062P60MH9
| PubChem = 10361702
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
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<!--Chemical data-->
| C=25 | H=36 | O=2
| smiles = C=3CC2C(C)(C)Oc(cc(cc1O)C4(CC4)CCCCCC)c1C2CC=3C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
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}}
'''AMG-41''' (part of the [[List of AM cannabinoids|AM cannabinoid series]]) is an [[analgesic]] drug which is a [[cannabinoid]] [[agonist]]. It is a derivative of
==
* [[AMG-3]]
* [[AMG-36]]
== References ==
{{reflist}}
{{cannabinoids}}
{{cannabinoid-stub}}▼
[[Category:Cannabinoids]]
[[Category:Benzochromenes]]
[[Category:Phenols]]
▲{{cannabinoid-stub}}
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Latest revision as of 21:46, 8 February 2024
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Chemical and physical data | |
Formula | C25H36O2 |
Molar mass | 368.561 g·mol−1 |
3D model (JSmol) | |
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AMG-41 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with a cyclopropyl group on the C1'-position of the C3-alkyl side chain. AMG-41 is a potent agonist at both CB1 and CB2, with a Ki of 0.44 nM at CB1 vs 0.86 nM at CB2.[1][2][3]
See also[edit]
References[edit]
- ^ Papahatjis DP, Nikas SP, Andreou T, Makriyannis A (December 2002). "Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols". Bioorganic & Medicinal Chemistry Letters. 12 (24): 3583–6. doi:10.1016/s0960-894x(02)00785-0. PMID 12443781.
- ^ Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A (July 2003). "Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'". Journal of Medicinal Chemistry. 46 (15): 3221–9. doi:10.1021/jm020558c. PMID 12852753.
- ^ Papahatjis DP, Nahmias VR, Nikas SP, Andreou T, Alapafuja SO, Tsotinis A, et al. (August 2007). "C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols". Journal of Medicinal Chemistry. 50 (17): 4048–60. doi:10.1021/jm070121a. PMID 17672444.