Cannabis Ruderalis

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AM-905
Identifiers
  • (6aR,9R,10aR)-3-[(E)-hept-1-enyl]-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
Chemical and physical data
FormulaC23H34O3
Molar mass358.513 g/mol g·mol−1
3D model (JSmol)
  • CCCCCC=Cc(cc1O)cc(OC(C)(C)C2CC3)c1C2CC3CO

AM-905 is an analgesic drug which is a cannabinoid agonist with a conformationally restricted side chain. It is a potent and reasonably selective agonist for the CB1 cannabinoid receptor, with a Ki of 1.2nM at CB1 vs 5.3nM at CB2.[1]

References

  1. ^ Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219
source: https://en.wikipedia.org/w/index.php?title=AM-905&oldid=211228808

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