Cannabis Ruderalis

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5F-MDMB-PICA is a potent [[agonist]] of both the [[Cannabinoid receptor type 1|CB<sub>1</sub> receptor]] and the [[Cannabinoid receptor type 2|CB<sub>2</sub> receptor]] with [[EC50|EC<sub>50</sub>]] values of 0.45&nbsp;nM and 7.4&nbsp;nM, respectively.<ref>{{cite journal | doi = 10.1021/acschemneuro.6b00137 | pmid = 27421060 | title = Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues | journal = ACS Chemical Neuroscience | volume = 7 | issue = 9 | pages = 1241–1254 | year = 2016 | last1 = Banister | first1 = Samuel D. | last2 = Longworth | first2 = Mitchell | last3 = Kevin | first3 = Richard | last4 = Sachdev | first4 = Shivani | last5 = Santiago | first5 = Marina | last6 = Stuart | first6 = Jordyn | last7 = Mack | first7 = James B. C. | last8 = Glass | first8 = Michelle | last9 = McGregor | first9 = Iain S. | last10 = Connor | first10 = Mark | last11 = Kassiou | first11 = Michael }}</ref>
5F-MDMB-PICA is a potent [[agonist]] of both the [[Cannabinoid receptor type 1|CB<sub>1</sub> receptor]] and the [[Cannabinoid receptor type 2|CB<sub>2</sub> receptor]] with [[EC50|EC<sub>50</sub>]] values of 0.45&nbsp;nM and 7.4&nbsp;nM, respectively.<ref>{{cite journal | doi = 10.1021/acschemneuro.6b00137 | pmid = 27421060 | title = Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues | journal = ACS Chemical Neuroscience | volume = 7 | issue = 9 | pages = 1241–1254 | year = 2016 | last1 = Banister | first1 = Samuel D. | last2 = Longworth | first2 = Mitchell | last3 = Kevin | first3 = Richard | last4 = Sachdev | first4 = Shivani | last5 = Santiago | first5 = Marina | last6 = Stuart | first6 = Jordyn | last7 = Mack | first7 = James B. C. | last8 = Glass | first8 = Michelle | last9 = McGregor | first9 = Iain S. | last10 = Connor | first10 = Mark | last11 = Kassiou | first11 = Michael }}</ref>


In the United States, 5F-MDMB-PICA is a [[Schedule I Controlled Substance]].<ref name="fedreg-Apr-2019">{{cite web | title = Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I | url = https://www.federalregister.gov/documents/2019/04/16/2019-07460/schedules-of-controlled-substances-temporary-placement-of-5f-edmb-pinaca-5f-mdmb-pica-fub-akb48 | publisher = Federal Register | date = 2019-04-16 }}</ref>
In the United States, 5F-MDMB-PICA is a [[Schedule I Controlled Substance]].<ref name="fedreg-Apr-2019">{{cite web | title = Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I | url = https://www.federalregister.gov/documents/2019/04/16/2019-07460/schedules-of-controlled-substances-temporary-placement-of-5f-edmb-pinaca-5f-mdmb-pica-fub-akb48 | publisher = Federal Register | date = 2019-04-16 }}</ref> In December of 2019, the [[UNODC]] announced scheduling recommendations placing 5F-MDMB-PICA into Schedule II.<ref>{{cite web|url=https://www.unodc.org/LSS/Announcement/Details/021820a0-8746-42a4-9ee3-47ce50b30ca3|title=December 2019 – WHO: World Health Organization recommends 12 NPS for scheduling}}</ref>


==References==
==References==

Revision as of 03:41, 17 January 2020

5F-MDMB-PICA
Clinical data
Other names5F-MDMB-2201; 5-Fluoro MDMB-PICA
Legal status
Legal status
Identifiers
  • Methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC21H29FN2O3
Molar mass376.472 g·mol−1
3D model (JSmol)
  • O=C(N[C@H](C(OC)=O)C(C)(C)C)C1=CN(CCCCCF)C2=C1C=CC=C2
  • InChI=1S/C21H29FN2O3/c1-21(2,3)18(20(26)27-4)23-19(25)16-14-24(13-9-5-8-12-22)17-11-7-6-10-15(16)17/h6-7,10-11,14,18H,5,8-9,12-13H2,1-4H3,(H,23,25)/t18-/m1/s1
  • Key:CHSUEEBESACQDV-GOSISDBHSA-N

5F-MDMB-PICA is a designer drug and synthetic cannabinoid.[1][2] In 2018, it was the fifth-most common synthetic cannabinoid identified in drugs seized by the Drug Enforcement Agency.[3]

5F-MDMB-PICA is a potent agonist of both the CB1 receptor and the CB2 receptor with EC50 values of 0.45 nM and 7.4 nM, respectively.[4]

In the United States, 5F-MDMB-PICA is a Schedule I Controlled Substance.[5] In December of 2019, the UNODC announced scheduling recommendations placing 5F-MDMB-PICA into Schedule II.[6]

References

  1. ^ Risseeuw, Martijn D.P.; Blanckaert, Peter; Coopman, Vera; Van Quekelberghe, Stijn; Van Calenbergh, Serge; Cordonnier, Jan (2017). "Identification of a new tert -leucinate class synthetic cannabinoid in powder and "spice-like" herbal incenses: Methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA)". Forensic Science International. 273: 45–52. doi:10.1016/j.forsciint.2017.01.023. PMID 28214755.
  2. ^ Mogler, Lukas; Franz, Florian; Rentsch, Daniel; Angerer, Verena; Weinfurtner, Georg; Longworth, Mitchell; Banister, Samuel D.; Kassiou, Michael; Moosmann, Bjoern; Auwärter, Volker (2018). "Detection of the recently emerged synthetic cannabinoid 5F-MDMB-PICA in 'legal high' products and human urine samples". Drug Testing and Analysis. 10 (1): 196–205. doi:10.1002/dta.2201. PMID 28371476.
  3. ^ "Emerging Threat Report: Annual 2018" (PDF). Special Testing and Research Laboratory, Drug Enforcement Administration.
  4. ^ Banister, Samuel D.; Longworth, Mitchell; Kevin, Richard; Sachdev, Shivani; Santiago, Marina; Stuart, Jordyn; Mack, James B. C.; Glass, Michelle; McGregor, Iain S.; Connor, Mark; Kassiou, Michael (2016). "Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues". ACS Chemical Neuroscience. 7 (9): 1241–1254. doi:10.1021/acschemneuro.6b00137. PMID 27421060.
  5. ^ "Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I". Federal Register. 2019-04-16.
  6. ^ "December 2019 – WHO: World Health Organization recommends 12 NPS for scheduling".
source: https://en.wikipedia.org/w/index.php?title=5F-MDMB-PICA&diff=prev&oldid=936173030

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