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Names | |
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IUPAC name
(3R)-6′′,6′′-Dimethyl-6′′H-pyrano[2′′,3′′:7,8]isoflavan-2′,4′-diol
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Systematic IUPAC name
4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H,8H-(benzo[1,2-b:3,4-b′]dipyran)-3-yl]benzene-1,3-diol | |
Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.126.141 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C20H20O4 | |
Molar mass | 324.376 g·mol−1 |
Appearance | Yellowish-brown powder |
Melting point | 238–240 °C (460–464 °F; 511–513 K)[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Glabridin is a chemical compound that is found in the root extract of licorice (Glycyrrhiza glabra).[2] Glabridin is an isoflavane, a type of isoflavonoid. This product is part of a larger family of plant-derived molecules, the natural phenols. Glabridin effectively inhibits platelet activation, so it might become therapeutic agent for thromboembolic disorders.[3]
It is used as an ingredient in cosmetics and is listed in International Nomenclature of Cosmetic Ingredients (INCI).
Glabridin is yellowish-brown powder. It is insoluble in water, but soluble in organic solvents such as propylene glycol.
See also
[edit]References
[edit]- ^ SciFinder Record for CAS#59870-68-7
- ^ Kinoshita T, Kajiyama K, Hiraga Y, Takahashi K, Tamura Y, Mizutani K (1996). "Isoflavan derivatives from Glycyrrhiza glabra (licorice)". Heterocycles. 43 (3): 581–588.
- ^ Chung CL, Chen JH, Huang WC, Sheu JR, Hsia CW, Jayakumar T, Hsia CH, Chiou KR, Hou SM (September 2022). "Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice". International Journal of Molecular Sciences. 23 (19): 11372. doi:10.3390/ijms231911372. PMC 9570097. PMID 36232674.
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