Cytochrome P450, family 105, also known as CYP105, is a cytochrome P450 monooxygenase family in bacteria, predominantly found in the phylum Actinomycetota and the order Actinomycetales.[2][3] The first three genes and subfamilies identified in this family is the herbicide-inducible P-450SU1 (CYP105A1, subfamily A) and P-450SU2 (CYP105B1, subfamily B) from Streptomyces griseolus[4][5] and choP (CYP105C1, subfamily C) from Streptomyces sp's cholesterol oxidase promoter region.[6][1]
Subfamily[edit]
| Subfamily[7] | first gene identified | Species | REF |
|---|---|---|---|
| A | SU1 (CYP105A1) | Streptomyces griseolus | [4] |
| B | SU2 (CYP105B1) | Streptomyces griseolus | [4] |
| C | choP (CYP105C1) | Streptomyces sp | [6] |
| D | soyC (CYP105D1) | Streptomyces griseus | [8] |
| E | ORF1 (CYP105E1) | Rhodococcus fascians | [9] |
Application[edit]
CYP105 enzymes is widely used in industry, such as the production of pravastatin.[3]
References[edit]
- ^ a b Nebert, DW; Nelson, DR; Coon, MJ; Estabrook, RW; Feyereisen, R; Fujii-Kuriyama, Y; Gonzalez, FJ; Guengerich, FP; Gunsalus, IC; Johnson, EF (January 1991). "The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature". DNA and Cell Biology. 10 (1): 1–14. doi:10.1089/dna.1991.10.1. PMID 1991046.
- ^ Moody SC, Loveridge EJ (December 2014). "CYP105-diverse structures, functions and roles in an intriguing family of enzymes in Streptomyces". Journal of Applied Microbiology. 117 (6): 1549–63. doi:10.1111/jam.12662. PMC 4265290. PMID 25294646.
- ^ a b Yasuda, K; Sugimoto, H; Hayashi, K; Takita, T; Yasukawa, K; Ohta, M; Kamakura, M; Ikushiro, S; Shiro, Y; Sakaki, T (January 2018). "Protein engineering of CYP105s for their industrial uses". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1866 (1): 23–31. doi:10.1016/j.bbapap.2017.05.014. PMID 28583351.
- ^ a b c Omer, CA; Lenstra, R; Litle, PJ; Dean, C; Tepperman, JM; Leto, KJ; Romesser, JA; O'Keefe, DP (June 1990). "Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus". Journal of Bacteriology. 172 (6): 3335–45. doi:10.1128/jb.172.6.3335-3345.1990. PMC 209144. PMID 2345149.
- ^ Hussain, HA; Ward, JM (January 2003). "Enhanced heterologous expression of two Streptomyces griseolus cytochrome P450s and Streptomyces coelicolor ferredoxin reductase as potentially efficient hydroxylation catalysts". Applied and Environmental Microbiology. 69 (1): 373–82. Bibcode:2003ApEnM..69..373H. doi:10.1128/aem.69.1.373-382.2003. PMC 152428. PMID 12514018.
- ^ a b Horii, M; Ishizaki, T; Paik, SY; Manome, T; Murooka, Y (July 1990). "An operon containing the genes for cholesterol oxidase and a cytochrome P-450-like protein from a Streptomyces sp". Journal of Bacteriology. 172 (7): 3644–53. doi:10.1128/jb.172.7.3644-3653.1990. PMC 213338. PMID 2361941.
- ^ Cytochrome P450 Homepage Link
- ^ Trower, MK; Lenstra, R; Omer, C; Buchholz, SE; Sariaslani, FS (August 1992). "Cloning, nucleotide sequence determination and expression of the genes encoding cytochrome P-450soy (soyC) and ferredoxinsoy (soyB) from Streptomyces griseus". Molecular Microbiology. 6 (15): 2125–34. doi:10.1111/j.1365-2958.1992.tb01386.x. PMID 1406253. S2CID 24513397.
- ^ Crespi, M; Vereecke, D; Temmerman, W; Van Montagu, M; Desomer, J (May 1994). "The fas operon of Rhodococcus fascians encodes new genes required for efficient fasciation of host plants". Journal of Bacteriology. 176 (9): 2492–501. doi:10.1128/jb.176.9.2492-2501.1994. PMC 205384. PMID 8169198.
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction