… PGB is the active principle of a medical drug (Lyrica® and generic specialties … under the curve
values following the administration of saline (NaCl) or pregabalin (PGB) in … understanding of the
mechanisms by which psychoactive substances produce their potent rewarding effects …

… events occur in clinical trials of some medications such as selective serotonin reuptake … Pregabalin
is an α2δ calcium channel subunit ligand and analgesic,11–14 indicated in multiple … Early pain
responses were assessed in pregabalin- and placebo-treated patients who did or …

… Pregabalin has a higher potency than gabapentin thus requiring lower doses, recommended
dose of up to 600 mg/day in … Pregabalin (Lyrica) … In comparison, participants on pregabalin 300
mg/day reported no significant difference in pain reduction compared with placebo at the …

Voltage-gated calcium channels are important contributors to the transmission and processing
of nociceptive information in the primary afferent pain pathway. Several types of calcium channels
and their ancillary subunits are dysregulated in response to nerve injury or inflammation …

… cell surface expression, localization and transport and are thus important players in
calcium-dependent signaling … the relatively simpler situation in the Drosophila genetic model
containing two neuronal putative α 2 δ subunits, straightjacket and CG4587, and one Ca v 1 …

… Ai α-GFP … To further test whether different α2δ subunits regulate HVA currents selectively in different
sub-neuronal compartments, or different HVA … This Ca2+ component can be uncovered by bath
application of the potent, ubiquitous, and irreversible VGCC blocker Cd2+ (500 µM …