Protein-coding gene in the species Homo sapiens
Tumor necrosis factor receptor superfamily, member 19 , also known as TNFRSF19 and TROY is a human gene .[ 5]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TNF receptor associated factor (TRAF) family members, and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase -independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.[ 5]
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Kojima T, Morikawa Y, Copeland NG, et al. (2000). "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles" . J. Biol. Chem . 275 (27): 20742–7. doi :10.1074/jbc.M002691200 . PMID 10764796 .
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Park JB, Yiu G, Kaneko S, et al. (2005). "A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors" . Neuron . 45 (3): 345–51. doi :10.1016/j.neuron.2004.12.040 . PMID 15694321 .
Shao Z, Browning JL, Lee X, et al. (2005). "TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration" . Neuron . 45 (3): 353–9. doi :10.1016/j.neuron.2004.12.050 . PMID 15694322 .
Spanjaard RA, Whren KM, Graves C, Bhawan J (2007). "Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target" . Int. J. Cancer . 120 (6): 1304–10. doi :10.1002/ijc.22367 . PMID 17187358 .
Satoh J, Tabunoki H, Yamamura T, et al. (2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions". Neuropathol. Appl. Neurobiol . 33 (1): 99–107. doi :10.1111/j.1365-2990.2006.00787.x . PMID 17239012 . S2CID 36762956 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .