SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEFgene.[5][6][7]
PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM][7]
^Chen H, Nandi AK, Li X, Bieberich CJ (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Research. 62 (2): 338–340. PMID11809674.
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Yamada N, Tamai Y, Miyamoto H, Nozaki M (January 2000). "Cloning and expression of the mouse Pse gene encoding a novel Ets family member". Gene. 241 (2): 267–274. doi:10.1016/S0378-1119(99)00484-9. PMID10675039.
Chen H, Nandi AK, Li X, Bieberich CJ (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Research. 62 (2): 338–340. PMID11809674.
Feldman RJ, Sementchenko VI, Gayed M, Fraig MM, Watson DK (August 2003). "Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression". Cancer Research. 63 (15): 4626–4631. PMID12907642.
Ghadersohi A, Odunsi K, Lele S, Collins Y, Greco WR, Winston J, et al. (February 2004). "Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules". Oncology Reports. 11 (2): 453–458. doi:10.3892/or.11.2.453. PMID14719083.
Chen H, Bieberich CJ (January 2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF". Journal of Cellular Biochemistry. 94 (1): 168–177. doi:10.1002/jcb.20297. PMID15523673. S2CID46494570.
Wang Y, Feng L, Said M, Balderman S, Fayazi Z, Liu Y, et al. (May 2005). "Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site". Biochemistry. 44 (19): 7095–7106. doi:10.1021/bi047352t. PMID15882048.
Fowler M, Borazanci E, McGhee L, Pylant SW, Williams BJ, Glass J, et al. (January 2006). "RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region". Journal of Cellular Biochemistry. 97 (1): 1–17. doi:10.1002/jcb.20664. PMID16237704. S2CID20541109.
1yo5: Analysis of the 2.0A crystal structure of the protein-DNA complex of human PDEF Ets domain bound to the prostate specific antigen regulatory site
2dkx: Solution structure of the SAM_PNT-domain of ETS transcription factor PDEF (Prostate ets)