Pieri is an Italian surname. Notable people with the surname include:

• Alessandro Pieri (born 1963), Italian sprint canoeist
• Anna Pieri Brignole Sale (1765–1815), a Sienese noblewoman
• Claudio Pieri (1940–2018), Italian football referee
• Damon Pieri (born 1970), American football player
• Dario Pieri (born 1975), Italian former road bicycle racer
• Enrico Pieri (1934–2021), Italian child, survived a German massacre of Italian villagers during World War II
• Francesco Pieri (1902–1961), Italian Roman Catholic bishop
• Gianfranco Pieri (born 1937), retired Italian basketball player
• Giovanni Antonio De Pieri, known as il Zoppo Vicentino (1671–1751), Italian painter of the Baroque style
• Jessica Pieri (born 1997), Italian tennis player
• Louis Pieri (1897–1967), American basketball and ice hockey executive and coach
• Mario Pieri (1860–1913), Italian mathematician
• Mirko Pieri (born 1978), Italian football manager and former player
• Pieris Pieri (born 1996), Cypriot alpine ski racer
• Valentina Pieri (born 2006), Actress