Petrou (Greek: Πέτρου) is a Greek surname. People with this surname include:

• Maria Petrou (1953–2012), Greek-born British computer scientist
• Kostas Petrou (born 1959), British boxer of Greek Cypriot descent
• Nicolas Petrou (born 1967), Cypriot-born American fashion designer
• Sokratis Petrou (born 1979), Greek footballer
• Ioannis Petrou (born 1996), Greek rower
• David Michael Petrou, American film producer
• George Petrou, Greek conductor and pianist
• Aristos Petrou (born 1990), American musician known for being in the New Orleans duo Suicideboys
• Thomas Petrou, American social media personality