Ninein (s.m. Al Ninein) in dialetto Bolognese è il maiale.
Ninein is a protein that in humans is encoded by the NIN gene .[ 5] [ 6] [ 7]
Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.[ 7]
This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000100503 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021068 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta . 1492 (2–3): 513–6. doi :10.1016/S0167-4781(00)00127-5 . PMID 11004522 .
^ Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun . 279 (3): 989–95. doi :10.1006/bbrc.2000.4050 . PMID 11162463 .
^ a b c "Entrez Gene: NIN ninein (GSK3B interacting protein)" .
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Ou YY, Mack GJ, Zhang M, Rattner JB (2002). "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation". J. Cell Sci . 115 (Pt 9): 1825–35. doi :10.1242/jcs.115.9.1825 . PMID 11956314 .
Dammermann A, Merdes A (2002). "Assembly of centrosomal proteins and microtubule organization depends on PCM-1" . J. Cell Biol . 159 (2): 255–66. doi :10.1083/jcb.200204023 . PMC 2173044 . PMID 12403812 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Chen CH, Howng SL, Cheng TS, et al. (2003). "Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle". Biochem. Biophys. Res. Commun . 308 (4): 975–83. doi :10.1016/S0006-291X(03)01510-9 . PMID 12927815 .
Fritzler MJ, Zhang M, Stinton LM, Rattner JB (2004). "Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia" . BMC Pediatrics . 3 : 11. doi :10.1186/1471-2431-3-11 . PMC 222907 . PMID 14503922 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". Nat. Cell Biol . 6 (4): 319–27. doi :10.1038/ncb1105 . PMID 15048123 . S2CID 22767022 .
Vizmanos JL, Novo FJ, Román JP, et al. (2004). "NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder" . Cancer Res . 64 (8): 2673–6. doi :10.1158/0008-5472.CAN-04-0144 . PMID 15087377 .
Howng SL, Hsu HC, Cheng TS, et al. (2004). "A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors" . FEBS Lett . 566 (1–3): 162–8. doi :10.1016/j.febslet.2004.04.024 . PMID 15147888 .
Stillwell EE, Zhou J, Joshi HC (2006). "Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation" . Cell Cycle . 3 (7): 923–30. doi :10.4161/cc.3.7.947 . PMID 15190203 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Delgehyr N, Sillibourne J, Bornens M (2005). "Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function" . J. Cell Sci . 118 (Pt 8): 1565–75. doi :10.1242/jcs.02302 . PMID 15784680 .
Cheng TS, Chang LK, Howng SL, et al. (2006). "SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization" . Life Sci . 78 (10): 1114–20. doi :10.1016/j.lfs.2005.06.021 . PMID 16154161 .