NS16, NS 16, NS-16, NS.16, or variation, may refer to:

• Ang Mo Kio MRT station (station code NS16), Ang Mo Kio, Singapore; a mass transit station
• Dartmouth East (constituency N.S. 16), Nova Scotia, Canada; a provincial electoral district
• Paramaribo District (FIPS region code NS16), Suriname

• Blue Origin NS-16, a suborbital space tourism flight on 2021 July 20 from Blue Origin
• RAF N.S. 16, a British NS class airship

• NS (disambiguation)
• 16 (disambiguation)