Gene of the species Homo sapiens
Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene .[ 4] [ 5] [ 6]
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM][ 6]
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035121 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hazra TK, Kow YW, Hatahet Z, Imhoff B, Boldogh I, Mokkapati SK, Mitra S, Izumi T (Aug 2002). "Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions" . J Biol Chem . 277 (34): 30417–20. doi :10.1074/jbc.C200355200 . PMID 12097317 .
^ Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK (Sep 2007). "Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress" . J Biol Chem . 282 (39): 28474–84. doi :10.1074/jbc.M704672200 . PMC 2679419 . PMID 17686777 .
^ a b "Entrez Gene: NEIL2 nei like 2 (E. coli)" .
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