Mainstream may refer to:

• Mainstream (film), a 2020 American film

• Mainstream (fanzine), a science fiction fanzine
• Mainstream Publishing, a Scottish publisher
• Mainstream, a 1943 book by Hamilton Basso
• Mainstream: On the Global Culture War, a 2013 book by Frédéric Martel

• Mainstream jazz, a term coined in the 1950s to describe the form of jazz which was a continuation of the Swing era
• Mainstream (band), a late-1990s British shoegazer band, or their first album
• Mainstream (Fullerton College Jazz Band album), 1994
• Mainstream (Lloyd Cole and the Commotions album), 1987
• Mainstream (Quiet Sun album), 1975
• Mainstream EP, by Metric, 1998
• Mainstream Records, an American record label
• "Mainstream", a song by Thea Gilmore from the 2003 album Avalanche

• All pages with titles beginning with Mainstream
• All pages with titles containing Mainstream
• Mainstreaming (disambiguation)
• Mainline Protestant, a group of American denominations