Highway 443, or Route 443 may refer to the following roads.

• Manitoba Provincial Road 443

• Bundesautobahn 443

• Route 443 (Israel)

• Japan National Route 443

• Indiana State Road 443
• Louisiana Highway 443
• Maryland Route 443 (former)
• Nevada State Route 443
• New York State Route 443
• Pennsylvania Route 443
• Puerto Rico Highway 443