The following highways are numbered 354:

• Manitoba Provincial Road 354
• Nova Scotia Route 354
• Prince Edward Island Route 354
• Quebec Route 354
• Saskatchewan Highway 354

• Main road 354 (Hungary)

• Japan National Route 354

• Arkansas Highway 354
• Connecticut Route 354
• Georgia State Route 354
• Kentucky Route 354
• Maryland Route 354
• Montana Secondary Highway 354
• New York:
  • New York State Route 354
  • County Route 354 (Albany County, New York)
• Ohio State Route 354 (former)
• Puerto Rico Highway 354
• Tennessee State Route 354
• Texas State Highway 354
• Virginia State Route 354
• Wyoming Highway 354