The following highways are numbered 353:

• Manitoba Provincial Road 353
• Prince Edward Island Route 353

• National Highway 353 (India)

• Japan National Route 353

• Arkansas Highway 353
• Georgia State Route 353 (former)
• Kentucky Route 353
• Maryland Route 353
• Montana Secondary Highway 353
• New York:
  • New York State Route 353
  • County Route 353 (Albany County, New York)
• Ohio State Route 353
• Puerto Rico Highway 353
• South Carolina Highway 353
• Tennessee State Route 353
• Texas:
  • Texas State Highway 353 (former)
  • Texas State Highway Loop 353
• Virginia State Route 353
• Wyoming Highway 353