Jane Smith may refer to:

• Jane Smith (field hockey) (born 1969), British Olympic field hockey player
• Jane Smith (footballer), former association football player for New Zealand
• Jane Smith (diver) (born 1975), British Olympic diver

• Jane Lawrence (1915–2005), married name Jane Lawrence Smith, American actress and opera singer
• Hilda Worthington Smith (Jane Smith, 1888–1984), social worker and labor education specialist
• Jane Idleman Smith, scholar of Islam
• Jane Stewart Smith, Scottish painter and draughtswoman
• Jane Smith, a fictional character played by Angelina Jolie in the film Mr. & Mrs. Smith

• Sarah Jane Smith, fictional character from the Dr. Who TV series
• Jane Lomax-Smith (born 1950), South Australian politician
• Jane Slack-Smith (born 1966), Australian cyclist