Protein-coding gene in the species Homo sapiens
Probable histidyl-tRNA synthetase , mitochondrial is an enzyme that in humans is encoded by the HARS2 gene .[5] [6]
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids . The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases . Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis . The gene is located in a head-to-head orientation with HARS on chromosome five , where the homologous genes share a bidirectional promoter.[6]
Freist W, Verhey JF, Rühlmann A, et al. (1999). "Histidyl-tRNA synthetase" . Biol. Chem . 380 (6): 623–46. doi :10.1515/BC.1999.079 . PMID 10430027 .
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . S2CID 7827573 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Lama J, Trono D (1998). "Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3" . J. Virol . 72 (2): 1671–6. doi :10.1128/JVI.72.2.1671-1676.1998 . PMC 124654 . PMID 9445076 .
Tsui HW, Mok S, de Souza L, et al. (1993). "Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element". Gene . 131 (2): 201–8. doi :10.1016/0378-1119(93)90294-D . PMID 8406012 .
Raben N, Borriello F, Amin J, et al. (1992). "Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases" . Nucleic Acids Res . 20 (5): 1075–81. doi :10.1093/nar/20.5.1075 . PMC 312093 . PMID 1549469 .