Exonuclease VII, large subunit | |||||||||
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Identifiers | |||||||||
Symbol | Exonuc_VII_L | ||||||||
Pfam | PF02601 | ||||||||
InterPro | IPR020579 | ||||||||
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Exonuclease VII small subunit | |||||||||
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![]() crystal structure of exodeoxyribonuclease vii small subunit (np_881400.1) from bordetella pertussis at 2.40 a resolution | |||||||||
Identifiers | |||||||||
Symbol | Exonuc_VII_S | ||||||||
Pfam | PF02609 | ||||||||
InterPro | IPR003761 | ||||||||
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The enzyme exodeoxyribonuclease VII (EC 3.1.11.6, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, exodeoxyribonuclease VII) is a bacterial exonuclease enzyme.[1][2] It is composed of two nonidentical subunits; one large subunit and 4 small ones.[3] that catalyses exonucleolytic cleavage in either 5′- to 3′- or 3′- to 5′-direction to yield nucleoside 5′-phosphates. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.
References
[edit]- ^ Chase, J.W.; Richardson, C.C. (1974). "Ribonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4545–4552. doi:10.1016/S0021-9258(19)42453-8. PMID 4602029.
- ^ Chase, J.W.; Richardson, C.C. (1974). "Exonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4553–4561. doi:10.1016/S0021-9258(19)42454-X. PMID 4602030.
- ^ Vales LD, Rabin BA, Chase JW (August 1982). "Subunit structure of Escherichia coli exonuclease VII". J. Biol. Chem. 257 (15): 8799–805. doi:10.1016/S0021-9258(18)34201-7. PMID 6284744.