Blood and Water may refer to:

• Blood and Water (short story collection), by Tim Winton
• Blood & Water, a comic book by Judd Winick and Tomm Coker
• On Earth's Remotest Bounds: Year One: Blood and Water, a novel by Kenneth C. Flint

• Blood and Water (Canadian TV series), a 2015 Canadian drama television series
• Blood & Water (South African TV series), a 2020 South African mystery drama television series
• "Blood and Water" (All Saints)
• "Blood and Water" (The Shield)
• "Blood and Water," an episode of All Creatures Great and Small
• Blood and Water, an installment of the TV series Ghosts, directed by Terry Johnson

• "Blood and Water" (song), by Palm Springs
• The final of Jesus Christ's Holy Wounds

• Blood is thicker than water