Palermo is the principal city and administrative seat of Sicily, Italy.

Palermo may also refer to:

• Palermo, Buenos Aires, neighborhood of the Argentine capital, Buenos Aires
• Palermo (Buenos Aires Underground), a railway station
• Palermo, Ontario, former village merged into the town of Oakville, Ontario, Canada
• Palermo, Huila, a town in Colombia
• Palermo, California
• Palermo, Kansas
• Palermo, Maine
• Palermo, New York
• Palermo, North Dakota
• Palermo, Uruguay, town in the department of Florida, Uruguay
• Palermo, Montevideo, neighborhood of the Uruguayan capital, Montevideo
• Province of Palermo, where the Sicilian city of Palermo is located
• Parque Palermo

• Palermo (surname), including a list of people with the name.
• Palermo Bajo, Argentine sports club based in Córdoba
• Palermo's Pizza, pizza company from Milwaukee, Wisconsin
• Palermo (film), 1937 Argentine film
• U.S. Città di Palermo, Italian football team which currently plays in Serie B
• Palermo Stone, archaeological find held by Regional Archeological Museum in the city of Palermo, Sicily
• Palermo Technical Impact Hazard Scale
• Alto Palermo, shopping mall located in Buenos Aires, Argentina
• Palermo, character of the Netflix television show Money Heist roled by Rodrigo de la Serna