Mende may refer to:

• Mende people
• Mende language
• Seim language, also called Mende language
• Mende syllabary (Kikakui)

• Mende (surname)
• Mende Nazer (born c.1982), Sudanese-British author and human rights activist

• various geographic designations in the department of Lozère, France:
  • Arrondissement of Mende
  • Mende, Lozère
  • Roman Catholic Diocese of Mende
• Mende (Chalcidice), a city in ancient Greece
• Mende, Hungary, a village in Pest county
• Mount Mende, Antarctica