Protein-coding gene in the species Homo sapiens
POLK Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T94 , 2LSI , 2OH2 , 2W7O , 2W7P , 3IN5 , 3PZP , 4BA9 , 4GK5 , 4U6P , 4U7C
Identifiers Aliases POLK , DINB1, DINP, POLQ, polymerase (DNA) kappa, DNA polymerase kappaExternal IDs OMIM : 605650 MGI : 1349767 HomoloGene : 32140 GeneCards : POLK Wikidata
DNA polymerase kappa is a DNA polymerase that in humans is encoded by the POLK gene . It is involved in translesion synthesis .[4] [5] [6]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000122008 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H (Aug 2000). "Error-prone bypass of certain DNA lesions by the human DNA polymerase κ" . Genes Dev . 14 (13): 1589–94. doi :10.1101/gad.14.13.1589 . PMC 316741 . PMID 10887153 .
^ Gerlach VL, Aravind L, Gotway G, Schultz RA, Koonin EV, Friedberg EC (Nov 1999). "Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily" . Proc Natl Acad Sci U S A . 96 (21): 11922–7. Bibcode :1999PNAS...9611922G . doi :10.1073/pnas.96.21.11922 . PMC 18388 . PMID 10518552 .
^ "Entrez Gene: POLK Polymerase (DNA directed) kappa" .
Further reading [ edit ]
Bavoux C, Hoffmann JS, Cazaux C (2005). "Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa". Biochimie . 87 (7): 637–46. doi :10.1016/j.biochi.2005.02.007 . PMID 15989980 .
Ogi T, Kato T, Kato T, Ohmori H (2000). "Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB" . Genes Cells . 4 (11): 607–18. doi :10.1046/j.1365-2443.1999.00289.x . PMID 10620008 . S2CID 6554870 .
Johnson RE, Prakash S, Prakash L (2000). "The human DINB1 gene encodes the DNA polymerase Polθ" . Proc. Natl. Acad. Sci. U.S.A . 97 (8): 3838–43. Bibcode :2000PNAS...97.3838J . doi :10.1073/pnas.97.8.3838 . PMC 18103 . PMID 10760255 .
Gerlach VL, Feaver WJ, Fischhaber PL, Friedberg EC (2001). "Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene" . J. Biol. Chem . 276 (1): 92–8. doi :10.1074/jbc.M004413200 . PMID 11024016 .
Haracska L, Unk I, Johnson RE, et al. (2002). "Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA" . Mol. Cell. Biol . 22 (3): 784–91. doi :10.1128/MCB.22.3.784-791.2002 . PMC 133560 . PMID 11784855 .
Washington MT, Johnson RE, Prakash L, Prakash S (2002). "Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini" . Proc. Natl. Acad. Sci. U.S.A . 99 (4): 1910–4. Bibcode :2002PNAS...99.1910W . doi :10.1073/pnas.032594399 . PMC 122293 . PMID 11842189 .
Suzuki N, Ohashi E, Kolbanovskiy A, et al. (2002). "Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(−)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)". Biochemistry . 41 (19): 6100–6. doi :10.1021/bi020049c . PMID 11994005 .
Fischhaber PL, Gerlach VL, Feaver WJ, et al. (2002). "Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides" . J. Biol. Chem . 277 (40): 37604–11. doi :10.1074/jbc.M206027200 . PMID 12145297 .
Bergoglio V, Bavoux C, Verbiest V, et al. (2003). "Localisation of human DNA polymerase kappa to replication foci". J. Cell Sci . 115 (Pt 23): 4413–8. doi :10.1242/jcs.00162 . PMID 12414988 . S2CID 84437951 .
Haracska L, Prakash L, Prakash S (2003). "Role of human DNA polymerase κ as an extender in translesion synthesis" . Proc. Natl. Acad. Sci. U.S.A . 99 (25): 16000–5. doi :10.1073/pnas.252524999 . PMC 138554 . PMID 12444249 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Wolfle WT, Washington MT, Prakash L, Prakash S (2003). "Human DNA polymerase κ uses template–primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions" . Genes Dev . 17 (17): 2191–9. doi :10.1101/gad.1108603 . PMC 196459 . PMID 12952891 .
Haracska L, Prakash L, Prakash S (2003). "A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair" . Genes Dev . 17 (22): 2777–85. doi :10.1101/gad.1146103 . PMC 280626 . PMID 14630940 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Suzuki N, Itoh S, Poon K, et al. (2004). "Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa". Biochemistry . 43 (20): 6304–11. doi :10.1021/bi0360298 . PMID 15147214 .
Ohashi E, Murakumo Y, Kanjo N, et al. (2005). "Interaction of hREV1 with three human Y-family DNA polymerases". Genes Cells . 9 (6): 523–31. doi :10.1111/j.1356-9597.2004.00747.x . PMID 15189446 . S2CID 24470762 .
Washington MT, Minko IG, Johnson RE, et al. (2004). "Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ" . Mol. Cell. Biol . 24 (13): 5687–93. doi :10.1128/MCB.24.13.5687-5693.2004 . PMC 480884 . PMID 15199127 .
Uljon SN, Johnson RE, Edwards TA, et al. (2005). "Crystal structure of the catalytic core of human DNA polymerase kappa" . Structure . 12 (8): 1395–404. doi :10.1016/j.str.2004.05.011 . PMID 15296733 .
External links [ edit ]
Overview of all the structural information available in the PDB for UniProt : Q9UBT6 (DNA polymerase kappa) at the PDBe-KB .