Retinal G protein coupled receptor

AliasesRGR, RP44, Retinal G protein coupled receptor
External IDsOMIM: 600342 MGI: 1929473 HomoloGene: 37709 GeneCards: RGR
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for RGR
Genomic location for RGR
Band10q23.1Start84,230,666 bp[1]
End84,259,960 bp[1]
RNA expression pattern
PBB GE RGR 207070 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 10: 84.23 – 84.26 MbChr 14: 37.03 – 37.05 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

RPE-retinal G protein-coupled receptor also known as RGR-opsin is a protein that in humans is encoded by the RGR gene.[5][6]


RGR-opsin is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain.[7][8] RGR-opsin preferentially binds all-trans-retinal,[8] which is the dominant form in the dark adapted retina,upon light exposure it is isomerized to 11-cis-retinal.[9] Therefore, RGR-opsin presumably acts as a photoisomerase to convert all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates. 11-cis-retinal is isomerized back within rhodopsin and the iodopsins in the rods and cones of the retina. RGR-opsin is exclusively expressed in tissue close to the rods and cones, the retinal pigment epithelium (RPE) and Müller cells.[7] RGR-opsin may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). RGR-opsin comes in different isoforms produced by alternative splicing.[6]


RGR-opsin has been shown to interact with KIAA1279.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148604 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021804 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen XN, Korenberg JR, Jiang M, Shen D, Fong HK (Jun 1996). "Localization of the human RGR opsin gene to chromosome 10q23". Human Genetics. 97 (6): 720–2. doi:10.1007/BF02346179. PMID 8641686.
  6. ^ a b "Entrez Gene: RGR retinal G protein coupled receptor".
  7. ^ a b Jiang M, Pandey S, Fong HK (Dec 1993). "An opsin homologue in the retina and pigment epithelium". Investigative Ophthalmology & Visual Science. 34 (13): 3669–78. PMID 8258527.
  8. ^ a b Shen D, Jiang M, Hao W, Tao L, Salazar M, Fong HK (Nov 1994). "A human opsin-related gene that encodes a retinaldehyde-binding protein". Biochemistry. 33 (44): 13117–25. doi:10.1021/bi00248a022. PMID 7947717.
  9. ^ Hao, W; Fong, HK (5 March 1999). "The endogenous chromophore of retinal G protein-coupled receptor opsin from the pigment epithelium". The Journal of Biological Chemistry. 274 (10): 6085–90. doi:10.1074/jbc.274.10.6085. PMID 10037690.
  10. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.