O-774 structure.png
PubChem CID
Chemical and physical data
Formula C25H35NO2
Molar mass 381.550 g/mol g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)

O-774 is a classical cannabinoid derivative which acts as a potent agonist for the cannabinoid receptors, with a Ki of 0.6 nM at CB1, and very potent cannabinoid effects in animal studies.[1][2]

See also[edit]


  1. ^ Singer M, et al. Potent cyano and carboxamido side-chain analogues of 1′, 1′-dimethyl-Δ8-tetrahydrocannabinol. Journal of Medicinal Chemistry. 1998 Oct 22;41(22):4400-7. PMID 9784115
  2. ^ The Cannabinoid Receptors. Part I. Cannabinoid Receptor Ligands and Structure-Activity Relationships. pp 6-9. Edited by Patricia H Reggio. Humana Press 2009. ISBN 978-1-58829-712-9