Nonabine

Nonabine
Nonabine.png
Clinical data
ATC code
  • none
Legal status
Legal status
  • Not approved for any medical use
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC25H33NO2
Molar mass379.544 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Nonabine (BRL-4664) is an experimental drug which is a synthetic THC analog.[1] It was studied in the 1980s for the prevention of nausea and vomiting associated with cancer chemotherapy but was never marketed.[1] It has strong antiemetic effects equivalent to those of chlorpromazine, and also produces some mild sedative effects, along with dry mouth and EEG changes typical of cannabinoid agonists, but with minimal changes in mood or perception, suggesting the abuse potential is likely to be low.[2][3]

References[edit]

  1. ^ a b Staquet, M.; Bron, D.; Rozencweig, M.; Kenis, Y. (1981). "Clinical studies with a THC analog (BRL-4664) in the prevention of cisplatin-induced vomiting". Journal of Clinical Pharmacology. 21 (S1): 60S–63S. doi:10.1002/j.1552-4604.1981.tb02575.x. PMID 7197692.
  2. ^ Archer, C. B.; Amlot, P. L.; Trounce, J. R. (1983). "Antiemetic effect of nonabine in cancer chemotherapy: A double blind study comparing nonabine and chlorpromazine". British Medical Journal (Clinical Research Ed.). 286 (6362): 350–1. doi:10.1136/bmj.286.6362.350-a. PMC 1546960. PMID 6402096.
  3. ^ McClelland, G. R.; Sutton, J. A. (1985). "Pilot investigation of the quantitative EEG and clinical effects of ketazolam and the novel antiemetic nonabine in normal subjects". Psychopharmacology. 85 (3): 306–8. doi:10.1007/BF00428192. PMID 2860687.