List of designer drugs

An assortment of several designer drugs.

Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal. Some designer drugs (research chemicals) are structural analogues of psychoactive tryptamines or phenethylamines but there are many other chemically unrelated psychoactive substances that can be considered part of the designer drug group.[1][2][3][4] Designer drugs also include analogues of controlled anabolic steroids. The pharmaceutical activities of these compounds might not be predictable based strictly upon structural examination. Many of the substances have common effects while structurally different or different effects while structurally similar due to SAR paradox. As a result of no real official naming for some of these compounds, as well as regional naming, this can all lead to potentially hazardous mix ups for users.[5] The following list is not exhaustive.

Psychedelics[edit]

A psychedelic substance is a psychoactive drug whose primary action is to alter cognition and perception. Psychedelics tend to affect and explore the mind in ways that result in the experience being qualitatively different from those of ordinary consciousness. The psychedelic experience is often compared to non-ordinary forms of consciousness such as trance, meditation, yoga, religious ecstasy, dreaming and even near-death experiences.

Lysergamides[edit]

Lysergamides are amide derivatives of the alkaloid lysergic acid.

Tryptamines[edit]

Drugs containing the tryptamine moiety are typically substrates for the serotonin receptors, in keeping with their close structural resemblance to serotonin, a neurotransmitter.

Benzofurans[edit]

Phenethylamines[edit]

Drugs containing the phenethylamine moiety bear close structural resemblance to dopamine but substitution on the benzene ring gives rise to drugs with a much higher affinity for serotonin receptors.

2C-x[edit]

2C-x class of psychedelics are 2,5-dimethoxy-phenethylamine derivatives.

NBxx[edit]

DOx[edit]

The DOx family of psychedelics are also known as "substituted amphetamines" as they contain the amphetamine backbone but are substituted on the benzene ring. This gives rise to serotonin agonists similar to the 2C-X class but more resistant to elimination in the body.

Dissociatives[edit]

Dissociatives are a class of hallucinogens which distort perceptions of sight and sound and produce feelings of detachment - dissociation - from the environment and self. This is done through reducing or blocking signals to the conscious mind from other parts of the brain. Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances. Some, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing euphoria. Many dissociatives have general depressant effects and can produce sedation, respiratory depression, analgesia, anesthesia, and ataxia, as well as cognitive and memory impairment and amnesia.

Arylcyclohexylamines[edit]

Arylcyclohexylamines are the oldest and most widely used dissociatives. The class includes the well known anaesthetic, ketamine.

Diarylethylamines[edit]

Diarylethylamines began to appear on grey markets only as recently as 2013.

Misc[edit]

Piperazines[edit]

Piperazine containing designer drugs have effects similar to MDMA (ecstasy). This class of drugs are mimics of serotonin that activate 5-HT receptor subtypes that release norepinephrine and dopamine.

Empathogens[edit]

Empathogens are a class of psychoactive drugs that produce distinctive emotional and social effects similar to those of MDMA . Users of empathogens say the drugs often produce feelings of empathy, love, and emotional closeness to others.

MDxx[edit]

Substituted methylenedioxyphenethylamines (MDxx) are a large chemical class of derivatives of the phenethylamines, which includes many psychoactive drugs that act as entactogens, psychedelics, and/or stimulants, as well as entheogens.

Benzofurans[edit]

Benzofurans are similar in structure to MD(M)A but differ in that the methylenedioxy groups have been modified, removing one of the two oxygens in the methylenedioxy ring to render a benzofuran ring.

Miscellaneous polycyclic phenethylamines[edit]

Indane and tetralin-type phenethylamines are vaguely related to their amphetamine analogues.

Only one non-tryptamine indole has been sold, 5-IT. It shows strong MAOI activity.

  • 5-IT, 5-API, PAL-571

Tryptamines[edit]

Drugs containing the tryptamine moiety are typically substrates for the serotonin receptors, in keeping with their close structural resemblance to serotonin, a neurotransmitter.

  • αET, α-Ethyltryptamine, "Monase"
  • 5-MeO-αET, α,O-Diethylserotonin
  • αMT, α-Methyltryptamine, "Indopan"
  • 5-MeO-αMT, α,O-Dimethylserotonin

Amphetamines[edit]

Substituted amphetamines are a chemical class of stimulants, entactogens, hallucinogens, and other drugs. They feature a phenethylamine core with a methyl group attached to the alpha carbon resulting in amphetamine, along with additional substitutions.

  • 4-BA, 4-Bromoamphetamine, PBA
  • 4-CA, 4-Chloroamphetamine, PCA
  • 4-CMA, 4-Chloromethamphetamine, PCMA
  • 4-FA, 4-Fluoroamphetamine, PFA
  • 4-FMA, 4-Fluoromethamphetamine, PFMA
  • 4-MA, 4-Methylamphetamine, PAL-313
  • 4-MeOA, 4-Methoxyamphetamine, PMA, 4-MeO-A, "Death"
  • 4-MeOMA, 4-Methoxymethamphetamine, PMMA, 4-MeO-MA
  • 4-MTA, 4-Methylthioamphetamine
  • Methamnetamine, N-Methyl-PAL-287, Methylnaphetamine, MNT, MNA
  • MMA, 3-Methoxy-4-Methylamphetamine
  • 3-FEA, 3F-Ethamphetamine, 3-Fluoroethamphetamine

Stimulants[edit]

Stimulants produce a variety of different kinds of effects by enhancing the activity of the central and peripheral nervous systems. Common effects, which vary depending on the substance and dosage in question, may include enhanced alertness, awareness, wakefulness, endurance, productivity, and motivation, increased arousal, locomotion, heart rate, and blood pressure, and the perception of a diminished requirement for food and sleep.

Amphetamines[edit]

Amphetamines are a chemical class of stimulants, entactogens, hallucinogens, and other drugs. They feature a phenethylamine core with a methyl group attached to the alpha carbon resulting in amphetamine, along with additional substitutions.

Cathinones[edit]

Cathinones include some stimulants and entactogens, which are derivatives of cathinone. They feature a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon, along with additional substitutions.

Pyrrolidines and Pyrrolidinophenones[edit]

Pyrrolidines are amphetamines with a pyrrolidine group. Pyrrolidinophenones (also called Pyrovalerones) are cathinones (βk-amphetamines) with a pyrrolidine group.

Thiophenes[edit]

Thiophenes are stimulant drugs which are analogues of amphetamine or cathinone where the phenyl ring has been replaced by thiophene.

Tropanes and Piperidines[edit]

Tropane alkaloids occur in plants of the families erythroxylaceae (including coca). Piperidine and its derivatives are ubiquitous building blocks in the synthesis of many pharmaceuticals and fine chemicals.

Oxazolidines[edit]

Oxazolidines are a five-membered ring compounds consisting of three carbons, a nitrogen, and an oxygen. The oxygen and NH are the 1 and 3 positions, respectively. In oxazolidine derivatives, there is always a carbon between the oxygen and the nitrogen.

Phenylmorpholines[edit]

Phenylmorpholines are a class of stimulants containing a phenethylamine skeleton in which the terminal amine is incorporated into a morpholine ring.

Misc[edit]

Sedatives[edit]

Sedatives are substances that induces sedation by reducing irritability or excitement. At higher doses they may result in slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. Doses of sedatives such as benzodiazepines, when used as a hypnotic to induce sleep, tend to be higher than amounts used to relieve anxiety, whereas only low doses are needed to provide a peaceful effect. Sedatives can be misused to produce an overly-calming effect. In the event of an overdose or if combined with another sedative, many of these drugs can cause unconsciousness and even death.

Opioids[edit]

Opioids have pharmacologic actions resembling morphine and other components of opium.

Benzodiazepines[edit]

Thienodiazepines[edit]

GHB analogues[edit]

Methaqualone analogues[edit]

Misc[edit]

Synthetic cannabinoids[edit]

Agonists of the central cannabinoid receptor type 1 mimic the behavioral effects of cannabis.

Classical cannabinoids[edit]

Miscellaneous cannabinoids[edit]

Indazole based[edit]

Indazole containing cannabinoid receptor agonists include:

Indole based[edit]

Indole containing cannabinoid receptor agonists include:

Quinolinylindoles[edit]

Benzoylindoles[edit]

Adamantoylindoles[edit]

Naphthoylindoles[edit]

Phenylacetylindoles[edit]

Androgens[edit]

Androgenic anabolic steroids have approved medical uses as well as used illicitly as performance-enhancing drugs to build muscle mass and strength. Anabolic steroids that have been designed to evade detection in sport doping tests are known as "designer steroids".[96][97]

Testosterone based[edit]

DHT based[edit]

Estranes[edit]

SARMs[edit]

Selective androgen receptor modulators (SARMs) are a novel class of androgen receptor ligands. They are intended to maintain the desirable muscle building effects of anabolic steroids while reducing undesirable androgenic actions (e.g., increased risk of prostate cancer). SARMs that are more selective in their action potentially could be used for a wider range clinical indications than the relatively limited legitimate uses that anabolic steroids are currently approved for.[98]

Others[edit]

Peptides[edit]

GHRH analogues[edit]

GHRH analogues stimulate the release of growth hormone.

Growth hormone secretagogue receptor agonists[edit]

Agonists of the growth hormone secretagogue receptor regulate energy homeostasis and body weight.

Others[edit]

PDE5 inhibitors[edit]

PDE5 inhibitors are typically used to treat erectile dysfunction and improve sexual stamina.

Nootropics[edit]

Central nervous system stimulants [edit]

Hebbian version of the Yerkes–Dodson law

Systematic reviews and meta-analyses of clinical human research using low doses of certain central nervous system stimulants found that these drugs enhance cognition in healthy people.[104][105][106] In particular, the classes of stimulants that demonstrate cognition-enhancing effects in humans act as direct agonists or indirect agonists of dopamine receptor D1, adrenoceptor A2, or both types of receptor in the prefrontal cortex.[104][105][107][108] Relatively high doses of stimulants cause cognitive deficits.[107][108]

Racetams[edit]

Racetams, such as piracetam, oxiracetam, phenylpiracetam, and aniracetam, are often marketed as cognitive enhancers and sold over-the-counter.[114] A recent study found that piracetam supplements sold in the United States were inaccurately labeled.[114] Racetams are often referred to as nootropics, but this property is not well established.[115] The racetams have poorly understood mechanisms, although piracetam and aniracetam are known to act as positive allosteric modulators of AMPA receptors and appear to modulate cholinergic systems.[116]

According to the US Food and Drug Administration,

"Piracetam is not a vitamin, mineral, amino acid, herb or other botanical, or dietary substance for use by humans to supplement the diet by increasing the total dietary intake. Further, piracetam is not a concentrate, metabolite, constituent, extract or combination of any such dietary ingredient. [...] Accordingly, these products are drugs, under section 201(g)(1)(C) of the Act, 21 U.S.C. § 321(g)(1)(C), because they are not foods and they are intended to affect the structure or any function of the body. Moreover, these products are new drugs as defined by section 201(p) of the Act, 21 U.S.C. § 321(p), because they are not generally recognized as safe and effective for use under the conditions prescribed, recommended, or suggested in their labeling."[117]

Miscellaneous[edit]


Psychedelic microdosing is the novel practice of using sub-threshold doses (microdoses) of psychedelic drugs in an attempt to improve mood and cognition.[120] The efficacy of this has not been verified.[121][122]In a study examining the qualitative reports of 278 microdosers the researchers found that there were mixed results among users.[123] While some users reported positive effects such as improved mood and cognition, others paradoxically reported negative effects such as physiological discomfort and anxiety.[123] In one of the only double-blind, randomized studies to date, those given microdoses of LSD did not perform better than those given the placebo on cognitive tasks.[124]

See also[edit]

References[edit]

  1. ^ "EMCDDA–Europol 2013 Annual Report on the information exchange, risk assessment and control of new psychoactive substances (implementation of Council Decision 2005/387/JHA)". EMCDDA. July 2014. Retrieved 8 August 2014.
  2. ^ "EMCDDA–Europol 2012 Annual Report on the implementation of Council Decision 2005/387/JHA (New drugs in Europe, 2012)". EMCDDA. May 2013. Retrieved 8 August 2014.
  3. ^ "EMCDDA–Europol 2011 Annual Report on the (information exchange, risk assessment and control of new psychoactive substances) implementation of Council Decision 2005/387/JHA". EMCDDA. April 2012. Retrieved 8 August 2014.
  4. ^ "EMCDDA–Europol 2010 Annual Report on the implementation of Council Decision 2005/387/JHA". EMCDDA. May 2011. Retrieved 8 August 2014.
  5. ^ Shimizu E, Watanabe H, Kojima T, Hagiwara H, Fujisaki M, Miyatake R, et al. (January 2007). "Combined intoxication with methylone and 5-MeO-MIPT". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 31 (1): 288–91. doi:10.1016/j.pnpbp.2006.06.012. PMID 16876302.
  6. ^ Wagmann L, Richter LH, Kehl T, Wack F, Bergstrand MP, Brandt SD, et al. (July 2019). "In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures". Analytical and Bioanalytical Chemistry. 411 (19): 4751–4763. doi:10.1007/s00216-018-1558-9. PMID 30617391.
  7. ^ Brandt SD, Kavanagh PV, Westphal F, Stratford A, Elliott SP, Dowling G, et al. (August 2019). "Return of the lysergamides. Part V: Analytical and behavioural characterization of 1-butanoyl-d-lysergic acid diethylamide (1B-LSD)". Drug Testing and Analysis. 11 (8): 1122–1133. doi:10.1002/dta.2613. PMID 31083768.
  8. ^ "1B-LSD (solution)". Cayman Chemical.
  9. ^ "1cP-LSD (solution)". Cayman Chemical.
  10. ^ Brandt SD, Kavanagh PV, Westphal F, Stratford A, Odland AU, Klein AK, et al. (March 2020). "Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD)". Drug Testing and Analysis. doi:10.1002/dta.2789. PMID 32180350.
  11. ^ "4-AcO-DPT". PubChem.
  12. ^ "4-HO-DALT". Isomerdesign.
  13. ^ Uchiyama N, Miyazawa N, Kawamura M, Kikura-Hanajiri R, Goda Y (February 2010). "[Analysis of newly distributed designer drugs detected in the products purchased in fiscal year 2008]". Yakugaku Zasshi (in Japanese). 130 (2): 263–70. doi:10.1248/yakushi.130.263. PMID 20118651.
  14. ^ "5-MeO-MET". Isomerdesign.
  15. ^ "5-MeO-NiPT". Isomerdesign.
  16. ^ "McPT". New Synthetic Drugs Database.
  17. ^ Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine Von der Struktur zur Funktion. Nachtschatten Verlag AG. ISBN 978-3-03788-700-4.
  18. ^ "25B-NBF". Cayman Chemical. Retrieved 27 December 2014.
  19. ^ "25C-NBF". Cayman Chemical. Retrieved 27 December 2014.
  20. ^ "25iP-NBOMe". New Synthetic Drugs Database.
  21. ^ a b c d e f g Kaizaki-Mitsumoto A, Noguchi N, Yamaguchi S, Odanaka Y, Matsubayashi S, Kumamoto H, et al. (January 2016). "Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34, and escaline), eight cathinone derivatives, and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market". Forensic Toxicology. 34 (1): 108–114. doi:10.1007/s11419-015-0293-6. ISSN 1860-8965.
  22. ^ "Mescaline-NBOMe". Cayman Chemical. Retrieved 29 September 2015.
  23. ^ Morris H, Wallach J (2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis. 6 (7–8): 614–32. doi:10.1002/dta.1620. PMID 24678061.
  24. ^ "DB-MDBP". New Synthetic Drugs Database.
  25. ^ "Dimethylone". Forendex. Southern Association of Forensic Scientists. Archived from the original on 13 August 2014. Retrieved 13 August 2014.
  26. ^ "N,N-Dimethylpentylone". Cayman Chemical. Retrieved 29 September 2015.
  27. ^ "EFLEA". New Synthetic Drugs Database.
  28. ^ a b Uchiyama N, Shimokawa Y, Kikura-Hanajiri R, Demizu Y, Goda Y, Hakamatsuka T (1 July 2015). "N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products". Forensic Toxicology. 33 (2): 244–259. doi:10.1007/s11419-015-0268-7. PMC 4525202. PMID 26257833.
  29. ^ "5-MBPB". New Synthetic Drugs Database.
  30. ^ "2-FMC" (PDF). SWGDRUG. 2013. Retrieved 19 August 2014.
  31. ^ "2-Methylethcathinone". Cayman Chemical. Retrieved 6 September 2015.
  32. ^ "2-MMC" (PDF). SWGDRUG. 2013. Retrieved 19 August 2014.
  33. ^ "2,4-DMEC". New Synthetic Drugs Database.
  34. ^ "2,4-DMMC". New Synthetic Drugs Database.
  35. ^ "3-Chloromethcathinone". Cayman Chemical. Retrieved 29 September 2015.
  36. ^ "3-Ethylethcathinone". Cayman Chemical. Retrieved 29 September 2015.
  37. ^ "3-MeOMC". Cayman Chemical. Retrieved 27 December 2014.
  38. ^ "3-MEC" (PDF). SWGDRUG. 2013. Retrieved 19 August 2014.
  39. ^ "4-BEC". New Synthetic Drugs Database.
  40. ^ Harm S (11 April 1967). "US Patent 3313687 - Appetite-suppressing and weight reducing composition".
  41. ^ "4-CMC". Cayman Chemical. Retrieved 27 December 2014.
  42. ^ "4F-IVP". Cayman Chemical. Retrieved 29 September 2015.
  43. ^ "4-FPD". Cayman Chemical. Retrieved 7 April 2015.
  44. ^ a b c d e Uchiyama N, Matsuda S, Kawamura M, Shimokawa Y, Kikura-Hanajiri R, Aritake K, et al. (October 2014). "Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products". Forensic Science International. 243: 1–13. doi:10.1016/j.forsciint.2014.03.013. PMID 24769262.
  45. ^ "4-methyl-N,N-DMC". Cayman Chemical. Retrieved 7 April 2015.
  46. ^ Weiß JA, Taschwer M, Kunert O, Schmid MG (March 2015). "Analysis of a new drug of abuse: cathinone derivative 1-(3,4-dimethoxyphenyl)-2-(ethylamino)pentan-1-one". Journal of Separation Science. 38 (5): 825–8. doi:10.1002/jssc.201401052. PMID 25545103.
  47. ^ "NiPP". New Synthetic Drugs Database.
  48. ^ "βk-IVP". New Synthetic Drugs Database.
  49. ^ Gaspar H, Bronze S, Ciríaco S, Queirós CR, Matias A, Rodrigues J, et al. (July 2015). "4F-PBP (4'-fluoro-α-pyrrolidinobutyrophenone), a new substance of abuse: Structural characterization and purity NMR profiling". Forensic Science International. 252: 168–76. doi:10.1016/j.forsciint.2015.05.003. PMID 26005857.
  50. ^ Shintani-Ishida K, Nakamura M, Tojo M, Idota N, Ikegaya H (May 2015). "Identification and quantification of 4′-methoxy-α-pyrrolidinobutiophenone (4-MeOPBP) in human plasma and urine using LC–TOF-MS in an autopsy case". Forensic Toxicology. 33 (2): 348–354. doi:10.1007/s11419-015-0281-x.
  51. ^ "5-PPDI". New Synthetic Drugs Database.
  52. ^ "α-PBT". Cayman Chemical. Retrieved 27 December 2014.
  53. ^ "TH-PVP". New Synthetic Drugs Database.
  54. ^ "5-BPDI". New Synthetic Drugs Database.
  55. ^ "3,4-MDPHP". Cayman Chemical. Retrieved 7 April 2015.
  56. ^ "PV-8". Forendex. Southern Association of Forensic Scientists. Archived from the original on 13 August 2014. Retrieved 13 August 2014.
  57. ^ "4-MeO-PV-9". Cayman Chemical. Retrieved 27 December 2014.
  58. ^ "PV-10". Cayman Chemical. Retrieved 7 April 2015.
  59. ^ "Isophenmetrazine". New Synthetic Drugs Database.
  60. ^ "3-FPE". New Synthetic Drugs Database.
  61. ^ "Phenmetetrazine". New Synthetic Drugs Database.
  62. ^ McLaughlin G, Baumann MH, Kavanagh PV, Morris N, Power JD, Dowling G, et al. (September 2018). "Synthesis, analytical characterization, and monoamine transporter activity of the new psychoactive substance 4-methylphenmetrazine (4-MPM), with differentiation from its ortho- and meta- positional isomers" (PDF). Drug Testing and Analysis. 10 (9): 1404–1416. doi:10.1002/dta.2396. PMID 29673128.
  63. ^ "Phenetrazine". New Synthetic Drugs Database.
  64. ^ Power JD, Scott KR, Gardner EA, Curran McAteer BM, O'Brien JE, Brehon M, et al. (January 2014). "The syntheses, characterization and in vitro metabolism of nitracaine, methoxypiperamide and mephtetramine". Drug Testing and Analysis. 6 (7–8): 668–75. doi:10.1002/dta.1616. PMID 24574100.
  65. ^ "Modafiendz". New Synthetic Drugs Database.
  66. ^ Oldenhof S, Ten Pierick A, Bruinsma J, Eustace S, Hulshof J, van den Berg J, Hoitink M (January 2020). "Identification of a novel fentanyl analog: p-Hydroxy-butyrylfentanyl". Drug Testing and Analysis. 12 (1): 152–155. doi:10.1002/dta.2695. PMID 31518047.
  67. ^ Kennedy NM, Schmid CL, Ross NC, Lovell KM, Yue Z, Chen YT, et al. (October 2018). "Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias". Journal of Medicinal Chemistry. 61 (19): 8895–8907. doi:10.1021/acs.jmedchem.8b01136. PMC 6386185. PMID 30199635.
  68. ^ Krotulski AJ, Mohr AL, Papsun DM, Logan BK (January 2018). "Metabolism of novel opioid agonists U-47700 and U-49900 using human liver microsomes with confirmation in authentic urine specimens from drug users". Drug Testing and Analysis. 10 (1): 127–136. doi:10.1002/dta.2228. PMID 28608586.
  69. ^ "2-(3,4-Dichlorophenyl)-N-[(1S,2S)-2-(dimethylamino)cyclohexyl]-N-methylacetamide". ChemSpider.
  70. ^ "Cloniprazepam". New Synthetic Drugs Database. Archived from the original on 2016-06-23. Retrieved 2016-06-03.
  71. ^ Huppertz LM, Bisel P, Westphal F, Franz F, Auwärter V, Moosmann B (April 2015). "Characterization of the four designer benzodiazepines clonazolam, deschloroetizolam, flubromazolam, and meclonazepam, and identification of their in vitro metabolites". Forensic Toxicology. 33 (2): 388–395. doi:10.1007/s11419-015-0277-6.
  72. ^ "EG-018". Cayman Chemical. Retrieved 9 August 2014.
  73. ^ a b c Mogler L, Franz F, Wilde M, Huppertz LM, Halter S, Angerer V, et al. (September 2018). "Phase I metabolism of the carbazole-derived synthetic cannabinoids EG-018, EG-2201, and MDMB-CHMCZCA and detection in human urine samples". Drug Testing and Analysis. 10 (9): 1417–1429. doi:10.1002/dta.2398. PMID 29726116.
  74. ^ "EG-2201". Cayman Chemical. Retrieved 27 October 2015.
  75. ^ "MDMB-CHMCZCA". New Synthetic Drugs Database.
  76. ^ a b c Qian Z, Jia W, Li T, Hua Z, Liu C (January 2017). "Identification and analytical characterization of four synthetic cannabinoids ADB-BICA, NNL-1, NNL-2, and PPA(N)-2201". Drug Testing and Analysis. 9 (1): 51–60. doi:10.1002/dta.1990. PMID 27239006.
  77. ^ Krotulski AJ, Mohr AL, Kacinko SL, Fogarty MF, Shuda SA, Diamond FX, et al. (September 2019). "4F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework". Journal of Forensic Sciences. 64 (5): 1451–1461. doi:10.1111/1556-4029.14101. PMID 31260580.
  78. ^ Haschimi B, Mogler L, Halter S, Giorgetti A, Schwarze B, Westphal F, et al. (September 2019). "Detection of the recently emerged synthetic cannabinoid 4F-MDMB-BINACA in "legal high" products and human urine specimens". Drug Testing and Analysis. 11 (9): 1377–1386. doi:10.1002/dta.2666. PMID 31228224.
  79. ^ "5C-APINACA". New Synthetic Drugs Database.
  80. ^ "5F-MN-18". Forendex. Southern Association of Forensic Scientists. Archived from the original on 12 August 2014. Retrieved 12 August 2014.
  81. ^ "5F-NPB-22". Cayman Chemical. Retrieved 9 May 2015.
  82. ^ "5F-SDB-005". Forendex. Southern Association of Forensic Scientists. Archived from the original on 13 August 2014. Retrieved 13 August 2014.
  83. ^ a b Qian Z, Hua Z, Liu C, Jia W (January 2016). "Four types of cannabimimetic indazole and indole derivatives, ADB-BINACA, AB-FUBICA, ADB-FUBICA, and AB-BICA, identified as new psychoactive substances". Forensic Toxicology. 34 (1): 133–143. doi:10.1007/s11419-015-0297-2. PMC 4705129. PMID 26793280.
  84. ^ "AMB". Forendex. Southern Association of Forensic Scientists. Archived from the original on 13 August 2014. Retrieved 13 August 2014.
  85. ^ Krotulski AJ, Mohr AL, Diamond FX, Logan BK (January 2020). "Detection and characterization of the new synthetic cannabinoid APP-BINACA in forensic casework". Drug Testing and Analysis. 12 (1): 136–144. doi:10.1002/dta.2698. PMID 31788963.
  86. ^ Nakajima JI, Takahashi M, Uemura N, Seto T, Fukaya H, Suzuki J, et al. (November 2014). "Identification of N,N-bis(1-pentylindol-3-yl-carboxy)naphthylamine (BiPICANA) found in an herbal blend product in the Tokyo metropolitan area and its cannabimimetic effects evaluated by in vitro [35S]GTPγS binding assays". Forensic Toxicology. 33: 84–92. doi:10.1007/s11419-014-0253-6.
  87. ^ "EMB-FUBINACA". New Synthetic Drugs Database.
  88. ^ "FUB-NPB-22". Cayman Chemical. Retrieved 9 May 2015.
  89. ^ "NPB-22". Cayman Chemical. Retrieved 9 May 2015.
  90. ^ Banister SD, Moir M, Stuart J, Kevin RC, Wood KE, Longworth M, et al. (September 2015). "Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA". ACS Chemical Neuroscience. 6 (9): 1546–59. doi:10.1021/acschemneuro.5b00112. PMID 26134475.
  91. ^ "5F-PY-PICA". New Synthetic Drugs Database.
  92. ^ "AMB-CHMICA". New Synthetic Drugs Database.
  93. ^ Mogler L, Wilde M, Huppertz LM, Weinfurtner G, Franz F, Auwärter V (May 2018). "Phase I metabolism of the recently emerged synthetic cannabinoid CUMYL-PEGACLONE and detection in human urine samples". Drug Testing and Analysis. 10 (5): 886–891. doi:10.1002/dta.2352. PMID 29314750.
  94. ^ "CBL-018". Cayman Chemical. Retrieved 26 October 2015.
  95. ^ Wiley JL, Lefever TW, Cortes RA, Marusich JA (September 2014). "Cross-substitution of Δ9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats". Pharmacology, Biochemistry, and Behavior. 124: 123–8. doi:10.1016/j.pbb.2014.05.016. PMC 4150816. PMID 24887450.
  96. ^ Kazlauskas R (2010). Designer steroids. Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 195. pp. 155–85. doi:10.1007/978-3-540-79088-4_7. ISBN 978-3-540-79087-7. PMID 20020364.
  97. ^ Abushareeda W, Fragkaki A, Vonaparti A, Angelis Y, Tsivou M, Saad K, et al. (March 2014). "Advances in the detection of designer steroids in anti-doping". Bioanalysis. 6 (6): 881–96. doi:10.4155/bio.14.9. PMID 24702116.
  98. ^ Zhang X, Sui Z (February 2013). "Deciphering the selective androgen receptor modulators paradigm". Expert Opinion on Drug Discovery. 8 (2): 191–218. doi:10.1517/17460441.2013.741582. PMID 23231475.
  99. ^ Zhang X, Li X, Allan GF, Sbriscia T, Linton O, Lundeen SG, Sui Z (January 2007). "Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators". Bioorganic & Medicinal Chemistry Letters. 17 (2): 439–43. doi:10.1016/j.bmcl.2006.10.035. PMID 17079140.
  100. ^ Allan GF, Tannenbaum P, Sbriscia T, Linton O, Lai MT, Haynes-Johnson D, et al. (August 2007). "A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats". Endocrine. 32 (1): 41–51. doi:10.1007/s12020-007-9005-2. PMID 17992601.
  101. ^ Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y (2013). "Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression". Biological & Pharmaceutical Bulletin. 36 (9): 1460–5. doi:10.1248/bpb.b13-00231. PMID 23995658.
  102. ^ Takayama K, Noguchi Y, Aoki S, Takayama S, Yoshida M, Asari T, et al. (February 2015). "Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition". Journal of Medicinal Chemistry. 58 (3): 1544–9. doi:10.1021/jm501170d. PMID 25569186.
  103. ^ "Public Notification: "RigiRx Plus" Contains Undeclared Drug Ingredient". US FDA. 20 April 2012. Retrieved 15 August 2014.
  104. ^ a b c d Spencer RC, Devilbiss DM, Berridge CW (June 2015). "The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex". Biological Psychiatry. 77 (11): 940–50. doi:10.1016/j.biopsych.2014.09.013. PMC 4377121. PMID 25499957.
  105. ^ a b c d e Ilieva IP, Hook CJ, Farah MJ (June 2015). "Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis". Journal of Cognitive Neuroscience. 27 (6): 1069–89. doi:10.1162/jocn_a_00776. PMID 25591060.
  106. ^ a b c d e Bagot KS, Kaminer Y (April 2014). "Efficacy of stimulants for cognitive enhancement in non-attention deficit hyperactivity disorder youth: a systematic review". Addiction. 109 (4): 547–57. doi:10.1111/add.12460. PMC 4471173. PMID 24749160.
  107. ^ a b c d Wood S, Sage JR, Shuman T, Anagnostaras SG (January 2014). "Psychostimulants and cognition: a continuum of behavioral and cognitive activation". Pharmacological Reviews. 66 (1): 193–221. doi:10.1124/pr.112.007054. PMC 3880463. PMID 24344115.
  108. ^ a b c d e f g Malenka RC, Nestler EJ, Hyman SE, Holtzman DM (2015). "Chapter 14: Higher Cognitive Function and Behavioral Control". Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (3rd ed.). New York: McGraw-Hill Medical. ISBN 9780071827706.
  109. ^ Urban KR, Gao WJ (2014). "Performance enhancement at the cost of potential brain plasticity: neural ramifications of nootropic drugs in the healthy developing brain". Frontiers in Systems Neuroscience. 8: 38. doi:10.3389/fnsys.2014.00038. PMC 4026746. PMID 24860437.
  110. ^ Battleday RM, Brem AK (November 2015). "Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review" (PDF). European Neuropsychopharmacology. 25 (11): 1865–81. doi:10.1016/j.euroneuro.2015.07.028. PMID 26381811.
  111. ^ Meulen Rt, Hall W, Mohammed A (2017). Rethinking Cognitive Enhancement. Oxford University Press. p. 116. ISBN 9780198727392.
  112. ^ Camfield DA, Stough C, Farrimond J, Scholey AB (August 2014). "Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis". Nutrition Reviews. 72 (8): 507–22. doi:10.1111/nure.12120. PMID 24946991.
  113. ^ Heishman SJ, Kleykamp BA, Singleton EG (July 2010). "Meta-analysis of the acute effects of nicotine and smoking on human performance". Psychopharmacology. 210 (4): 453–69. doi:10.1007/s00213-010-1848-1. PMC 3151730. PMID 20414766.
  114. ^ a b Cohen PA, Zakharevich I, Gerona R (2020). "Presence of Piracetam in Cognitive Enhancement Dietary Supplements". JAMA Internal Medicine. 180 (3): 458. doi:10.1001/jamainternmed.2019.5507. PMC 6902196. PMID 31764936.
  115. ^ Malenka RC, Nestler EJ, Hyman SE (2009). Sydor A, Brown RY (eds.). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. p. 454. ISBN 9780071481274.
  116. ^ Gualtieri F, Manetti D, Romanelli MN, Ghelardini C (2002). "Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs". Current Pharmaceutical Design. 8 (2): 125–38. doi:10.2174/1381612023396582. PMID 11812254.
  117. ^ John Gridley (30 August 2010). "FDA Warning Letter: Unlimited Nutrition". Office of Compliance, Center for Food Safety and Applied Nutrition, Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration. Retrieved 5 April 2016.
  118. ^ a b c d e f Fond G, Micoulaud-Franchi JA, Brunel L, Macgregor A, Miot S, Lopez R, et al. (September 2015). "Innovative mechanisms of action for pharmaceutical cognitive enhancement: A systematic review". Psychiatry Research. 229 (1–2): 12–20. doi:10.1016/j.psychres.2015.07.006. PMID 26187342.
  119. ^ Zajdel P, Bednarski M, Sapa J, Nowak G (2015). "Ergotamine and nicergoline - facts and myths". Pharmacol Rep. doi:10.1016/j.pharep.2014.10.010. PMID 25712664.CS1 maint: uses authors parameter (link)
  120. ^ Fadiman, James (2016-01-01). "Microdose research: without approvals, control groups, double blinds, staff or funding". Psychedelic Press. XV.
  121. ^ Webb, Megan; Copes, Heith; Hendricks, Peter S. (2019-08-01). "Narrative identity, rationality, and microdosing classic psychedelics". International Journal of Drug Policy. 70: 33–39. doi:10.1016/j.drugpo.2019.04.013. ISSN 0955-3959. PMID 31071597.
  122. ^ Polito, Vince; Stevenson, Richard J. (2019-02-06). "A systematic study of microdosing psychedelics". PLOS ONE. 14 (2): e0211023. doi:10.1371/journal.pone.0211023. ISSN 1932-6203. PMC 6364961. PMID 30726251.
  123. ^ a b Anderson, Thomas; Petranker, Rotem; Christopher, Adam; Rosenbaum, Daniel; Weissman, Cory; Dinh-Williams, Le-Anh; Hui, Katrina; Hapke, Emma (December 2019). "Psychedelic microdosing benefits and challenges: an empirical codebook". Harm Reduction Journal. 16 (1): 43. doi:10.1186/s12954-019-0308-4. ISSN 1477-7517. PMC 6617883. PMID 31288862.
  124. ^ Bershad, Anya K.; Schepers, Scott T.; Bremmer, Michael P.; Lee, Royce; Wit, Harriet de (2019-11-15). "Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers". Biological Psychiatry. 86 (10): 792–800. doi:10.1016/j.biopsych.2019.05.019. ISSN 0006-3223. PMC 6814527. PMID 31331617.