Flumetasone
Flumetasone.svg
Clinical data
Other namesFlumethasone (USAN)
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
Topical
ATC code
Pharmacokinetic data
MetabolismHepatic, CYP3A4-mediated
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.016.701 Edit this at Wikidata
Chemical and physical data
FormulaC22H28F2O5
Molar mass410.452 g/mol g·mol−1
3D model (JSmol)
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Flumetasone, also known as flumethasone,[1] is a corticosteroid for topical use.

It was patented in 1951 and approved for medical use in 1964.[2]

Chemistry[edit]

Flumethasone is 420 times as potent as cortisone in an animal model for anti-inflammatory activity.[citation needed]

Names[edit]

Trade names include Locacorten, Locorten, and Orsalin. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis. It is usually formulated as the pivalic acid ester prodrug flumetasone pivalate.

See also[edit]

References[edit]

  1. ^ Morton, IK; Hall, JM (1999). Concise Dictionary of Pharmacological Agents Properties and Synonyms. Dordrecht: Springer Netherlands. p. 122. ISBN 9789401144391.
  2. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 484. ISBN 9783527607495.