Aliases FZD3, Fz-3, frizzled class receptor 3
External IDs MGI: 108476 HomoloGene: 23004 GeneCards: FZD3
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)

Genomic location for FZD3
Genomic location for FZD3
Band 8p21.1 Start 28,494,205 bp[1]
End 28,574,267 bp[1]
RNA expression pattern
PBB GE FZD3 219683 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 8: 28.49 – 28.57 Mb Chr 14: 65.19 – 65.26 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.[5][6][7]


This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[7]

The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[8][9]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104290Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007989Ensembl, May 2017
  3. ^ “Human PubMed Reference:”.
  4. ^ “Mouse PubMed Reference:”.
  5. ^ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). “Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21”. Biochem Biophys Res Commun. 271 (1): 8–14. doi:10.1006/bbrc.2000.2578. PMID 10777673.
  6. ^ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). “Identification, gene structure, and expression of human frizzled-3 (FZD3)”. Biochem Biophys Res Commun. 273 (1): 27–34. doi:10.1006/bbrc.2000.2882. PMID 10873558.
  7. ^ a b “Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)”.
  8. ^ Hua ZL, Smallwood PM, Nathans J (Dec 2013). “Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons”. eLife. 2: e01482. doi:10.7554/eLife.01482. PMC 3865743. PMID 24347548.
  9. ^ Hua ZL, Jeon S, Caterina MJ, Nathans J (Jul 2014). “Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system”. Proc Natl Acad Sci U S A. 111 (29): E3005–14. doi:10.1073/pnas.1406399111. PMC 4115534. PMID 24799694.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.