Drinabant

Drinabant
Drinabant.svg
Drinabant ball-and-stick model.png
Clinical data
ATC code
  • None
Legal status
Legal status
  • Development terminated
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C23H20Cl2F2N2O2S
Molar mass 497.385 g/mol g·mol−1
3D model (JSmol)

Drinabant (INN; AVE-1625) is a drug that acts as a selective CB1 receptor antagonist, which was under investigation varyingly by Sanofi-Aventis as a treatment for obesity, schizophrenia, Alzheimer’s disease, Parkinson’s disease, and nicotine dependence.[1][2][3] Though initially studied as a potential treatment for a variety of different medical conditions, Sanofi-Aventis eventually narrowed down the therapeutic indications of the compound to just appetite suppression. Drinabant reached phase IIb clinical trials for this purpose in the treatment of obesity but was shortly thereafter discontinued,[4] likely due to the observation of severe psychiatric side effects including anxiety, depression, and thoughts of suicide in patients treated with the now-withdrawn rimonabant, another CB1 antagonist that was also under development by Sanofi-Aventis.[5]

In late 2018, the drug was licensed by Opiant Pharmaceuticals, which intends to develop it for the treatment of acute cannabinoid overdose (ACO) as an injectable for administration in an emergency department setting. Opiant claims that ACO is most frequently linked to the ingestion of “edibles” containing large quantities of D9-tetrahydrocannabinol (THC) and synthetic cannabinoids (“K2” and “spice”) that are more potent and less expensive than marijuana. Edibles, sold as brownies, cookies and candies, pose particular risks for children, who often consume these by accident. It estimates that based on 2014 rates from the National Emergency Department sample and United States Census Bureau figures, that ACO resulted in more than one million emergency department visits in the United States in 2016. With an increasing number of states legalizing marijuana for personal and recreational use, ACO rates are expected to rise. Symptoms of ACO produced by edibles and synthetic cannabinoids can include panic and anxiety, feelings of paranoia, agitation, visual and auditory hallucinations, and nausea. These symptoms often require emergency medical attention and can take six or more hours to resolve (Winstock, et al., J Psychopharmacology 2015). There are currently no approved treatments for ACO.

See also[edit]

References[edit]

  1. ^ Lange JH, Kruse CG (2008). “Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives”. Chemical Record (New York, N.Y.). 8 (3): 156–68. doi:10.1002/tcr.20147. PMID 18563799.
  2. ^ Kwon MO, Herrling P (2005). “List of drugs in development for neurodegenerative diseases. Update September 2005”. Neuro-Degenerative Diseases. 2 (2): 61–108. doi:10.1159/000089285. PMID 16909049.
  3. ^ Gerald Litwack (14 August 2009). Anandamide. Academic Press. p. 172. ISBN 978-0-12-374782-2. Retrieved 13 May 2012.
  4. ^ Reggio, Patricia H. (2009). “Toward the design of cannabinoid CB1 receptor inverse agonists and neutral antagonists”. Drug Development Research. 70 (8): 585–600. doi:10.1002/ddr.20337. ISSN 0272-4391.
  5. ^ Lee HK, Choi EB, Pak CS (2009). “The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents”. Current Topics in Medicinal Chemistry. 9 (6): 482–503. doi:10.2174/156802609788897844. PMID 19689362.