3D model (JSmol)
|Molar mass||314.469 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Cannabichromene (CBC), also called cannabichrome, cannanbichromene, pentylcannabichromene or cannabinochromene, is one of the 120 cannabinoids found in the Cannabis plant, and is therefore a phytocannabinoid. It bears structural similarity to the other natural cannabinoids, including tetrahydrocannabinol (THC), tetrahydrocannabivarin (THCV), cannabidiol (CBD), and cannabinol (CBN), among others. Cannabichromene and its derivatives are as abundant as cannabinols in cannabis. It is not active at CB1 or CB2 receptors, but is an agonist of TRPA1 and less potently, an agonist of TRPV3 and TRPV4. CBC has two stereoisomers. It is not scheduled by the Convention on Psychotropic Substances. “A body of literature The National Library of Medicine discusses shows data which recently demonstrated that the major non-THC phytocannabinoid, cannabichromene (CBC), promotes cell survival during differentiation while blunting cell differentiation into astroglia.”
Within the Cannabis plant, CBC occurs mainly as cannabichromenic acid (CBCA, 2-COOH-CBC, CBC-COOH). Geranyl pyrophosphate and olivetolic acid combine to produce cannabigerolic acid (CBGA; the sole intermediate for all other phytocannabinoids), which is cyclized by the enzyme CBCA synthase to form CBCA. Over time, or when heated somewhere above 200° F, CBCA is decarboxylated, producing CBC. See also the biosynthetic scheme image below.
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