CAS Number
PubChem CID
Chemical and physical data
Molar mass338.491 g·mol−1
3D model (JSmol)
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AMG-1 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.6 nM at CB1 vs 3.1 nM at CB2.[1][2]

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  1. ^ Papahatjis, Demetris P.; Nikas, Spyros P.; Kourouli, Therapia; Chari, Ravi; Xu, Wei; Pertwee, Roger G.; Makriyannis, Alexandros (2003). "Pharmacophoric Requirements for the Cannabinoid Side Chain. Probing the Cannabinoid Receptor Subsite at C1'". Journal of Medicinal Chemistry. 46 (15): 3221–3229. doi:10.1021/jm020558c. ISSN 0022-2623. PMID 12852753.
  2. ^ Keimowitz, Alison R.; Martin, Billy R.; Razdan, Raj K.; Crocker, Peter J.; Mascarella, S. Wayne; Thomas, Brian F. (2000). "QSAR Analysis of Δ8-THC Analogues: Relationship of Side-Chain Conformation to Cannabinoid Receptor Affinity and Pharmacological Potency". Journal of Medicinal Chemistry. 43 (1): 59–70. doi:10.1021/jm9902281. ISSN 0022-2623. PMID 10633038.