Legal status
Legal status
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass356.470 g·mol−1
3D model (JSmol)

AB-CHMINACA is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor (Ki = 0.78 nM) and CB2 receptor (Ki = 0.45 nM) and fully substitutes for Δ9-THC in rat discrimination studies, while being 16x more potent.[1][2] Continuing the trend seen in other cannabinoids of this generation,[which?] it contains a valine amino acid amide residue as part of its structure, where older cannabinoids contained a naphthyl or adamantane residue.

Side effects[edit]

There have been a number of reported cases of seizures, deaths, and psychotic episodes in relation to this synthetic cannabinoid.[3][4][5][6][7][8][9]

Legal status[edit]

In 2015, AB-CHMINACA became a Schedule I controlled substance in the United States.[10]

AB-CHMINACA is an Anlage II controlled substance in Germany as of May 2015.[11]

As of October 2015 AB-CHMINACA is a controlled substance in China.[12]

AB-CHMINACA is illegal in Switzerland as of December 2015.[13]

AB-CHMINACA is an illegal substance in Russian Federation.

See also[edit]


  1. ^ Jenny L Wiley; Julie A Marusich; Timothy W Lefever; Kateland R Antonazzo; Michael T Wallgren; Ricardo A Cortes; Purvi R Patel; Megan Grabenauer; Katherine N Moore & Brian F Thomas (September 2015). "AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice". Journal of Pharmacology and Experimental Therapeutics. 354 (3): 328–339. doi:10.1124/jpet.115.225326. PMC 4538877. PMID 26105953.
  2. ^ AB-CHMINACA, Cayman Chemicals
  3. ^ "N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide (AB-CHMINACA), N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and [1-(5-fluoropentyl)-1H-indazol-3-yl](naphthalen-1-yl)methanone (THJ-2201). Background Information and Evaluation of 'Three Factor Analysis' (Factors 4, 5, and 6) for Temporary Scheduling" (PDF). Drug Enforcement Administration. December 2014. Retrieved 7 August 2015.
  4. ^ Jamie Merrill (5 June 2015). "Vertex: Police warn of 'ticking time bomb' of potentially lethal cannabis substitute". The Independent. Retrieved 2 July 2015.
  5. ^ Jordan Trecki; Roy R. Gerona; Michael D. Schwartz (July 2015). "Synthetic Cannabinoid–Related Illnesses and Deaths". New England Journal of Medicine. 373 (2): 103–107. doi:10.1056/NEJMp1505328. PMID 26154784.
  6. ^ Amin Wurita; Koutaro Hasegawa; Kayoko Minakata; Kunio Gonmori; Hideki Nozawa; Itaru Yamagishi; Osamu Suzuki; Kanako Watanabe (March 2016). "Identification and quantification of metabolites of AB-CHMINACA in a urine specimen of an abuser". Legal Medicine. 19: 113–118. doi:10.1016/j.legalmed.2015.07.011. PMID 26257317.
  7. ^ Brittany Schock (30 September 2015). "No criminal charges in March death of Terrance Moxley". Richland Source. Retrieved 2 October 2015.
  8. ^ Joseph A. Tyndall; Roy Gerona; Giuliano De Portu; Jordan Trecki; Marie-Carmelle Elie; Judith Lucas; John Slish; Kenneth Rand; Lindsay Bazydlo; Martina Holder; Matthew F. Ryan; Paul Myers; Nicole Iovine; Michelle Plourde; Emily Weeks; James R. Hanley; Greg Endres; Danielle ST Germaine; Paul J. Dobrowolski; Michael Schwartz (November 2015). "An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA". Clinical Toxicology. 53 (10): 950–956. doi:10.3109/15563650.2015.1100306. PMID 26555732. S2CID 24724258.
  9. ^ Janez Klavž; Maksimiljan Gorenjak; Martin Marinšek (August 2016). "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC". Forensic Science International. 265: 121–124. doi:10.1016/j.forsciint.2016.01.018. PMID 26890319.
  10. ^ Drug Enforcement Administration, Department of Justice (30 January 2015). "Schedules of controlled substances: Temporary placement of three synthetic cannabinoids into schedule I. Final order" (PDF). Federal Register. 80 (20): 5042–5047. PMID 25730924.
  11. ^ "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)". Retrieved 22 June 2015.
  12. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
  13. ^ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien". Der Bundesrat.