THC Science

SLC5A4
Identifiers
Aliases	SLC5A4, DJ90G24.4, SAAT1, SGLT3, solute carrier family 5 member 4
External IDs	HomoloGene: 8591 GeneCards: SLC5A4
Gene location (Human)
Chr.	Chromosome 22 (human)
End	32,255,347 bp
RNA expression pattern
	Top expressed in
	More reference expression data
	n/a
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	6527
	n/a
	ENSG00000100191
	n/a
	Q9NY91
	n/a
	NM_014227
	n/a
	NP_055042
	n/a
	Wikidata
View/Edit Human

The low affinity sodium-glucose cotransporter also known as the sodium/glucose cotransporter 3 (SGLT3) or solute carrier family 5 member 4 (SLC5A4) is a protein that in humans is encoded by the SLC5A4 gene.^[3]^[4]^[5] It functions as a sugar sensor.

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100191 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".
^ Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (March 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.
^ Jung H (October 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.

Further reading[edit]

Munafò MR, Clark TG, Roberts KH, Johnstone EC (2006). "Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression". Neuropsychobiology. 53 (1): 1–8. doi:10.1159/000089915. PMID 16319503. S2CID 12803994.
Blaya C, Salum GA, Lima MS, Leistner-Segal S, Manfro GG (2007). "Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis". Behavioral and Brain Functions. 3: 41. doi:10.1186/1744-9081-3-41. PMC 1994953. PMID 17705872.
Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H (September 2003). "A glucose sensor hiding in a family of transporters". Proceedings of the National Academy of Sciences of the United States of America. 100 (20): 11753–8. Bibcode:2003PNAS..10011753D. doi:10.1073/pnas.1733027100. PMC 208830. PMID 13130073.
Fairchild TJ (January 2008). "Protection of muscle membrane excitability during cycling in humans: a role for SGLT3?". Journal of Applied Physiology. 104 (1): 315, author reply 316. doi:10.1152/japplphysiol.00793.2007. PMID 18198291. S2CID 29443314.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM (February 2007). "Imino sugars are potent agonists of the human glucose sensor SGLT3". Molecular Pharmacology. 71 (2): 628–34. doi:10.1124/mol.106.030288. PMID 17110502. S2CID 13642065.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100191 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".

[pmid9501190-4] Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (March 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.

[pmid12354616-5] Jung H (October 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.

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