Diacylglycerol lipase

diacylglycerol lipase, alpha
Identifiers
SymbolDAGLA
Alt. symbolsC11orf11
Entrez747
HUGO1165
RefSeqNM_006133
UniProtQ9Y4D2
Other data
EC number3.1.1.-
LocusChr. 11 q12.3
diacylglycerol lipase, beta
Identifiers
SymbolDAGLB
Entrez221955
HUGO28923
RefSeqNM_139179
UniProtQ8NCG7
Other data
EC number3.1.1.-
LocusChr. 7 p22.1

Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.[1] It catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol.

Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.

Inhibitors[edit]

The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.

References[edit]

External links[edit]