Ayahuasca is a brew of various psychoactive plants.
Ayahuasca may also refer to:
- Ayahuasca (Pelt album), 2001
- Ayahuasca (Baiyu album), 2013
- Ayahuasca: Welcome to the Work, a 2013 album by Ben Lee
- Banisteriopsis caapi, one of the main ingredients in ayahuasca
- "Ayahuasca" (song), a 2015 electronic track by Hoax23
- "Ayahuasca" (song), a 2016 single by Swedish-Italian singer Veronica Maggio
- Ayahuasca (song), a single by Jonathan Roy on Life Distortions album