|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||256.259 g/mol g·mol−1|
|3D model (JSmol)|
|(what is this?)|
8-Phenyltheophylline (8-phenyl-1,3-dimethylxanthine, 8-PT) is a drug derived from the xanthine family which acts as a potent and selective antagonist for the adenosine receptors A1 and A2A, but unlike other xanthine derivatives has virtually no activity as a phosphodiesterase inhibitor. It has stimulant effects in animals with similar potency to caffeine. Coincidentally 8-phenyltheophylline has also been found to be a potent and selective inhibitor of the liver enzyme CYP1A2 which makes it likely to cause interactions with other drugs which are normally metabolised by CYP1A2.
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- Rabe KF; Magnussen H; Dent G (April 1995). “Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants”. European Respiratory Journal. 8 (4): 637–42. PMID 7664866.
- Howell LL; Morse WH; Spealman RD (September 1990). “Respiratory effects of xanthines and adenosine analogs in rhesus monkeys”. The Journal of Pharmacology and Experimental Therapeutics. 254 (3): 786–91. PMID 2395111.
- Spealman RD (1988). “Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism”. Psychopharmacology. 95 (1): 19–24. doi:10.1007/bf00212759. PMID 3133696.
- Murray S; Odupitan AO; Murray BP; Boobis AR; Edwards RJ (March 2001). “Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline”. Xenobiotica. 31 (3): 135–51. doi:10.1080/00498250110043292. PMID 11465391.