Retinoic acid-inducible orphan G protein-coupled receptor

G protein-coupled receptor, family C, group 5, member A
Identifiers
SymbolGPRC5A
Alt. symbolsRAIG1, RAI3
Entrez9052
HUGO9836
OMIM604138
RefSeqNM_003979
UniProtQ8NFJ5
Other data
LocusChr. 12 p13-p12.3
G protein coupled receptor, family C, group 5, member B
Identifiers
SymbolGPRC5B
Alt. symbolsRAIG2
Entrez51704
HUGO13308
OMIM605948
RefSeqNM_016235
UniProtQ9NZH0
Other data
LocusChr. 16 p12
G protein-coupled receptor, family C, group 5, member C
Identifiers
SymbolGPRC5C
Alt. symbolsRAIG3
Entrez55890
HUGO13309
OMIM605949
RefSeqNM_022036
UniProtQ9NQ84
Other data
LocusChr. 17 q25
G protein-coupled receptor, family C, group 5, member D
Identifiers
SymbolGPRC5D
Entrez55507
HUGO13310
OMIM607437
RefSeqNM_018654
UniProtQ9NZD1
Other data
LocusChr. 12 p13.3

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.[1][2][3][4]

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.[5]

References[edit]

  1. ^ Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.
  2. ^ Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
  3. ^ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
  4. ^ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta. 1518 (3): 237–48. doi:10.1016/s0167-4781(01)00197-x. PMID 11311935.
  5. ^ Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). "Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling". Biochem. Biophys. Res. Commun. 358 (4): 968–75. doi:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.

External links[edit]