|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||312.497 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
JWH-133, alongside WIN 55,212-2 and HU-210, is responsible for preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer's Disease, in addition to preventing cognitive impairment and loss of neuronal markers . This anti-inflammatory action is induced through agonist action at the CB2 receptor, which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids at this receptor completely abolish neurotoxicity related to microglia activation in rat models.
As the U.S. Drug Enforcement Administration criminalizes any extract "containing one or more cannabinoids," JWH-133 is a scheduled substance in the U.S. This is despite the low potential for abuse relative to its sister compounds such as JWH-018, as JWH-133 is selective for the non-psychoactive CB2 receptor and thus lacks significant psychoactive effects.
- JNeurosci.org Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation Also has been shown to block grown of tumors. More clinical studies and trials are needed.