3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||415.42 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Cephalosporin C is an antibiotic of the cephalosporin class. It was isolated from fungi of the genus Acremonium and first characterized in 1961. Although not a very active antibiotic itself, synthetic analogs of cephalosporin C, such as cefalotin, became some of the first marketed cephalosporin antibiotic drugs.
Cephalosporin C strongly absorbs ultraviolet light, is stable to acid and penicillin, is non-toxic and has in vivo activity in mice. Cephalosporin C, which has a similar structure to penicillin N, was never commercialized.
Cephalosporins are used to treat bacterial infections such as respiratory tract infections, skin infections and urinary tract infections. When cephalosporins, along with any Antibiotic, is given as a treatment, take the medication for the fully prescribed time even if symptoms disappear.
These are allergic reactions to the drug and should seek medical attention:
- trouble breathing
- severe stomach cramps
- bloody diarrhea
- fast heartbeat
Cephalosporin C has weak activity to the staphylococci infection, which was 0.1% activity. This decrease in activity was due to the replacement of the D-α-aminoadipic acid side chain with phenylacetic acid.
The protein that cephalosporin C interacts with is Penicillin binding proteins.
Cephalosporin C is the product of the biosynthesis pathway of third generation cephalosporins. This is done by exchanging the acetyl CoA into DAC.
To achieve cephalosporin C as the end product, there are 6 genes reported to be in control of the pathway.
- Abraham, E. P.; Newton, G. G. F. (1961). "Structure of cephalosporin C". Biochemical Journal. 79 (2): 377–393. doi:10.1042/bj0790377. PMC 1205850. PMID 13681080.
- Kardos, Nelson; Demain, Arnold L. (November 2011). "Penicillin: the medicine with the greatest impact on therapeutic outcomes". Applied Microbiology and Biotechnology. 92 (4): 677–687. doi:10.1007/s00253-011-3587-6. ISSN 0175-7598. PMID 21964640.
- "CEPHALOSPORINS - INJECTION side effects, medical uses, and drug interactions". MedicineNet. Retrieved 2019-05-06.
- Singh, Khusbu; Mohapatra, Pradumna K.; Pati, Sanghamitra; Dwivedi, Gaurav Raj (2019). "Genetics and Molecular Biology of Genes Encoding Cephalosporin Biosynthesis in Microbes". New and Future Developments in Microbial Biotechnology and Bioengineering. pp. 25–34. doi:10.1016/B978-0-444-63503-7.00002-4. ISBN 9780444635037.